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American cranberry (Vaccinium macrocarpon) extract affects human prostate cancer cell growth via cell cycle arrest by modulating expression of cell cycle regulators

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Food & Function Vol - 3 Issue - 4

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Food & Function Vol -1

Soy foods and urinary isoprostanes: Results from a randomized study in premenopausal women

Content Provider	Royal Society of Chemistry (RSC)
Author	Maskarinec, Gertraud Sen, Cherisse Morimoto, Yukiko Cooney, Robert V. Heak, Sreang Franke, Adrian A.
Copyright Year	2012
Abstract	In addition to their antiestrogenic effects, soy isoflavones may protect against cancer through alternate biological actions, for example, antioxidant properties. This randomized crossover study explored the relationship between dietary isoflavone intake through common soy foods and oxidative stress quantified by urinary isoprostane levels. Eighty-two women aged 39.2 ± 6.1 years were randomly selected to receive a high soy diet of 2 soy food servings per day and a low soy diet of <3 servings per week for 6 months each, separated by a 1-month washout period. Urine samples were collected at baseline and at the end of each dietary period. Urinary isoprostane levels were measured using enzyme-linked immunosorbent assays (ELISA) and adjusted for creatinine levels. Mixed models using log-transformed values were applied to evaluate the effect of the high soy diet. Unadjusted isoprostane excretion levels were lower during the high rather than the low soy diet, but this effect was not statistically significant (p = 0.81). After adjustment for urinary creatinine, isoprostane excretion was slightly higher during the high soy diet (p = 0.02), an observation that was confirmed in a regression analysis between urinary isoflavones and isoprostanes during the high soy diet. The original association remained significant when restricted to adherent participants, however this effect disappeared after exclusion of three extreme values. In agreement with several previous reports, these findings do not support the hypothesis that soy exerts antioxidant effects, as measured by urinary isoprostane excretions, but additional markers of oxidative stress need to be investigated in future studies.
Starting Page	517
Ending Page	521
Page Count	5
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	3
Issue Number	5
Journal	Food & Function
DOI	10.1039/c2fo10251j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Soybean Isoflavones Cancer Antioxidant Crossover study Oxidative stress Isoprostane Creatinine Regression analysis
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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