NDLI: Fructose containing sugars modulate mRNA of lipogenic genes ACC and FAS and protein levels of transcription factors ChREBP and SREBP1c with no effect on body weight or liver fat

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Fructose containing sugars modulate mRNA of lipogenic genes ACC and FAS and protein levels of transcription factors ChREBP and SREBP1c with no effect on body weight or liver fat

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Food & Function Vol -2

Food & Function Vol -1

Fructose containing sugars modulate mRNA of lipogenic genes ACC and FAS and protein levels of transcription factors ChREBP and SREBP1c with no effect on body weight or liver fat

Content Provider	Royal Society of Chemistry (RSC)
Author	Janevski, Mile Lewandowski, Paul Siljanovski, Svetlana Cameron-Smith, David Ratnayake, Sunil McGlynn, Maree A.
Copyright Year	2012
Abstract	The aim of this study was to determine the effects of high-glucose, high-fructose and high-sucrose diets on weight gain, liver lipid metabolism and gene expression of proteins involved with hepatic fat metabolism. Rats were fed a diet containing either 60% glucose, 60% fructose, 60% sucrose, or a standard chow for 28 days. Results indicated that high-fructose and high-sucrose diets were associated with higher mRNA levels of gene transcripts involved with fat synthesis; ACC, FAS and ChREBP, with no change in SREBP-1C mRNA. The protein level of ChREBP and SREBP1c was similar in liver homogenates from all groups, but were higher in nuclear fractions from the liver of high-fructose and high-sucrose fed rats. The mRNA level of gene transcripts involved with fat oxidation was the same in all three diets, whilst a high-fructose diet was associated with greater amount of mRNA of the fat transporter CD36. Despite the changes in mRNA of lipogenic proteins, the body weight of animals from each group was the same and the livers from rats fed high-fructose and high-sucrose diets did not contain more fat than control diet livers. In conclusion, changing the composition of the principal monosaccharide in the diet to a fructose containing sugar elicits changes in the level of hepatic mRNA of lipogenic and fat transport proteins and protein levels of their transcriptional regulators; however this is not associated with any changes in body weight or liver fat content.
Starting Page	141
Ending Page	149
Page Count	9
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	3
Issue Number	2
Journal	Food & Function
DOI	10.1039/c1fo10111k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	ACC Liver Lipid Metabolism Gene Adipocyte Glucose Fructose Sucrose Messenger RNA Anterior cingulate cortex Fatty acid synthase Carbohydrate-responsive element-binding protein Protein CD36 Monosaccharide
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Fructose containing sugars modulate mRNA of lipogenic genes ACC and FAS and protein levels of transcription factors ChREBP and SREBP1c with no effect on body weight or liver fat

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