NDLI: Aryl hydrocarbon receptor potency of chlorinated parabens in the aquatic environment

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Research highlights: antibiotic resistance genes: from wastewater into the environment

Drinking water purity – a UK perspective

Can meta-omics help to establish causality between contaminant biotransformations and genes or gene products?

Sediment microbial fuel cells for wastewater treatment: challenges and opportunities

The consumptive water footprint of electricity and heat: a global assessment

Selective adsorption of oil–water mixtures using polydimethylsiloxane (PDMS)–graphene sponges

Impact of indigenous microbiota of subtidal sand on fecal indicator bacteria decay in beach systems: a microcosm study

Triclosan, chlorinated triclosan derivatives, and hydroxylated polybrominated diphenyl ethers (OH-BDEs) in wastewater effluents

Extracting metal ions from water with redox active biopolymer electrodes

Measuring poly(acrylamide) flocculants in fresh water using inter-polymer complex formation

Energy-efficient desalination by forward osmosis using responsive ionic liquid draw solutes

Membrane configuration influences microbial capacitive desalination performance

Optimizing the performance of a membrane bio-electrochemical reactor using an anion exchange membrane for wastewater treatment

A kinetic model of gene transfer via natural transformation of Azotobacter vinelandii

Aryl hydrocarbon receptor potency of chlorinated parabens in the aquatic environment

Biofilm formation of anoxygenic photosynthetic bacteria induced by phototaxis for enhancing hydrogen production

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Environmental Science: Water Research & Technology Vol - 1 Issue - 2

Environmental Science: Water Research & Technology Vol - 1 Issue - 1

Aryl hydrocarbon receptor potency of chlorinated parabens in the aquatic environment

Content Provider	Royal Society of Chemistry (RSC)
Author	Terasaki, Masanori Yasuda, Michiko Makino, Masakazu Shimoi, Kayoko
Copyright Year	2015
Abstract	Parabens are widely used as preservatives in personal care products. Parabens and their chlorinated by-products are continuously released into aquatic environments where aryl hydrocarbon receptor (AhR) potency was observed. Chlorinated parabens have structural similarities to hydroxylated polychlorinated biphenyls (PCBs, which also possess AhR potency) in the number of chlorine atoms and hydroxyl groups in the aromatic ring. The aryl hydrocarbon receptor potency of 24 compounds, including chlorinated and non-chlorinated parabens, degradation products of non-parabens, and possible degradation products of chlorinated parabens, was measured using a yeast (YCM3) reporter gene and cytochrome P450 (CYP)1, ethoxyresorufin O-deethylase (EROD) assays. We specifically focused on the AhR potency of parabens in water samples from swimming pools and from rivers receiving effluents from sewage treatment plants (STPs). The yeast assay revealed 16 compounds exhibiting AhR potency, with their potency relative to the AhR ligand β-naphthoflavone (BNF) ranging from 5 × 10−5 to 9 × 10−2. In human hepatoma cell line HepG2, four parabens caused significant induction of EROD activity (p < 0.05); contents of isobutyl paraben (iBP) and dichlorinated isopropyl paraben (Cl2iPP) in each treatment group were 2.6- and 1.8-fold greater, respectively, than that of the vehicle control at 100 μM. The occurrences of all compounds in swimming pool samples and of 20 compounds in river samples were analysed using gas chromatography-mass spectrometry, which revealed total concentrations of 2.7–1100 ng L−1 and 83–4600 ng L−1, respectively. Water samples exhibited AhR potency; their BNF equivalents ranged from 4.0 to 960 pM in pool water and from 25 to 3500 pM in river water. The contribution ratio of active compounds accounted for up to 6.3% (pool water) and 0.94% (river water) of the observed potency of water samples. This study provides the first confirmation of AhR-mediated toxicity of parabens using in vitro assays.
Starting Page	375
Ending Page	382
Page Count	8
File Format	HTM / HTML PDF
ISSN	20531400
Volume Number	1
Issue Number	3
Journal	Environmental Science: Water Research & Technology
DOI	10.1039/c5ew00047e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Aryl hydrocarbon receptor Chlorine Hydroxy group Saccharomyces cerevisiae Reporter gene Gene Cytochrome P450 Sewage treatment Ligand British National Formulary Butyl group Paraben Propyl group Gas chromatography\u2013mass spectrometry
Content Type	Text
Resource Type	Article
Subject	Environmental Engineering Water Science and Technology

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Evidence for an Aryl Hydrocarbon Receptor-Mediated Cytochrome P450 Autoregulatory (2007)

Evidence for an aryl hydrocarbon receptor-mediated cytochrome p450 autoregulatory (2007).

Aryl hydrocarbon receptor potency of chlorinated parabens in the aquatic environment

The occurrence of methyl, ethyl, propyl, and butyl parabens in the urban rivers and stormwaters of Sydney, Australia

Aryl hydrocarbon receptor-mediated gene (2009).

Induction of cytochrome P450-1A by the equine estrogen equilenin, a new endogenous aryl hydrocarbon receptor ligand

Aryl Hydrocarbon Receptor and Aryl Hydrocarbon Nuclear Translocator Expression in Human and Rat Placentas and Transcription Activity in Human Trophoblast Cultures

A Cyp1a2-Luciferase Transgenic CD-1 Mouse Model: Responses to Aryl Hydrocarbons Similar to the Humanized AhR Mice

Expression of Aryl Hydrocarbon Receptor Repressor in Normal Human Tissues and Inducibility by Polycyclic Aromatic Hydrocarbons in Human Tumor-Derived Cell Lines

Aryl hydrocarbon receptor potency of chlorinated parabens in the aquatic environment

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Aryl hydrocarbon receptor potency of chlorinated parabens in the aquatic environment