NDLI: Occurrence of artificial sweeteners in human liver and paired blood and urine samples from adults in Tianjin, China and their implications for human exposure

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Environmental Science: Processes & Impacts Vol - 18 Issue - 8

Environmental Science: Processes & Impacts Vol - 18 Issue - 7

Environmental Science: Processes & Impacts Vol - 18 Issue - 6

Environmental Science: Processes & Impacts Vol - 18 Issue - 5

Occurrence of artificial sweeteners in human liver and paired blood and urine samples from adults in Tianjin, China and their implications for human exposure

Content Provider	Royal Society of Chemistry (RSC)
Author	Gao, Chuanzi Li, Xiao Gan, Zhiwei Li, Yanxi Ma, Ling Sun, Hongwen Zhang, Tao
Copyright Year	2016
Abstract	In this study, acesulfame (ACE), saccharin (SAC) and cyclamate (CYC) were found in all paired urine and blood samples collected from healthy adults, with mean values of 4070, 918 and 628 ng mL−1, respectively, in urine and 9.03, 20.4 and 0.72 ng mL−1, respectively, in blood. SAC (mean: 84.4 ng g−1) and CYC (4.29 ng g−1) were detectable in all liver samples collected from liver cancer patients, while ACE was less frequently detected. Aspartame (ASP) was not found in any analyzed human sample, which can be explained by the fact that this chemical metabolized rapidly in the human body. Among all adults, significantly positive correlations between SAC and CYC levels were observed (p < 0.001), regardless of human matrices. Nevertheless, no significant correlations between concentrations of SAC (or CYC) and ACE were found in any of the human matrices. Our results suggest that human exposure to SAC and CYC is related, whereas ACE originates from a discrete source. Females (or young adults) were exposed to higher levels of SAC and CYC than males (or elderly). The mean renal clearance of SAC was 730 mL per day per kg in adults, which was significantly (p < 0.001) lower than those for CYC (10 800 mL per day per kg) and ACE (10 300 mL per day per kg). The average total daily intake of SAC and ACE was 9.27 and 33.8 μg per kg bw per day, respectively.
Starting Page	1169
Ending Page	1176
Page Count	8
File Format	HTM / HTML PDF
ISSN	20507887
Volume Number	18
Issue Number	9
Journal	Environmental Science: Processes & Impacts
DOI	10.1039/c6em00130k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	CYC Saccharin Sodium cyclamate Urine Liver Hepatocellular carcinoma Aspartame
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Public Health, Environmental and Occupational Health Management, Monitoring, Policy and Law

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