NDLI: DNA photonuclease activity of four new copper(ii) complexes under UV and red light: theoretical/experimental correlations with active species generation

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Dalton Transactions Vol - 39 Issue - 7

Dalton Transactions Vol - 39 Issue - 6

Dalton Transactions Vol - 39 Issue - 5

Dalton Transactions Vol -0

DNA photonuclease activity of four new copper(ii) complexes under UV and red light: theoretical/experimental correlations with active species generation

Content Provider	Royal Society of Chemistry (RSC)
Author	Bortolotto, Tiago Rocha, William R. Terenzi, Hernán Fischer, Franciele Luane Bortoluzzi, Adailton J. Souza, Bernardo de Ferreira, Dalva E. C. Neves, Ademir
Copyright Year	2010
Abstract	In this study, four new mononuclear copper(II) complexes, [Cu(L1)(dpq)]ClO4 (2), [Cu(L1)(phen)]ClO4 (3), [Cu(L2)(dpq)]ClO4 (4), [Cu(L1)(OAc)] (5), and the known complex [Cu(dpq)2(H2O)]ClO4 (1), were synthesized and characterized by various methods (dpq = dipyrido[3,2-d:2′,3′-h]quinoxaline, L1 = (3,5-di-tert-butyl-2-hydroxybenzyl)(2-pyridylmethyl)imine, L2 = (2-hydroxybenzyl)(2-pyridylmethyl)imine). The structure of [Cu(L1)(dpq)]ClO4 (2) was determined by X-ray crystallography and reveals that the CuII center is coordinated by dpq and by the N2O donor ligand L1 in a distorted square pyramidal arrangement. The interaction of 1–5 with calf thymus DNA was measured and the binding constant Kb was obtained for the complexes, with values strongly dependent on the intercalating and/or binding properties of the ligands present in the structure of each complex. Also, the nuclease and photonuclease activity in terms of plasmid DNA cleavage with addition of reactants was monitored, in order to verify the mechanism through which the complexes cleave DNA. The complexes displayed good activity under both UV (365 nm) and red light (635 nm) irradiation, with the Type II mechanism prevailing in the case of the former and Type I mechanism for the latter. Finally, two new correlations between the experimental and theoretical parameters are discussed and some hypotheses regarding the active species generation are proposed.
Starting Page	2027
Ending Page	2035
Page Count	9
File Format	HTM / HTML PDF
ISSN	14779226
Volume Number	39
Issue Number	8
Journal	Dalton Transactions
DOI	10.1039/b920122j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Copper Water Quinoxaline Imine X-ray crystallography Ligand Thymus DNA Binding constant Plasmid
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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