NDLI: Anaerobic DNA cleavage activity in red light and photocytotoxicity of (pyridine-2-thiol)cobalt(iii) complexes of phenanthroline bases

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Dalton Transactions Vol - 39 Issue - 6

Dalton Transactions Vol - 39 Issue - 5

Dalton Transactions Vol -0

Anaerobic DNA cleavage activity in red light and photocytotoxicity of (pyridine-2-thiol)cobalt(iii) complexes of phenanthroline bases

Content Provider	Royal Society of Chemistry (RSC)
Author	Chakravarty, Akhil R. Roy, Sovan Majumdar, Ritankar Dighe, Rajan R. Saha, Sounik Lahiri, Debojyoti
Copyright Year	2010
Abstract	Cobalt(III) complexes [Co(pnt)(B)2](NO3)2 (1–3) of pyridine-2-thiol (pnt) and phenanthroline bases (B), viz. 1,10-phenanthroline (phen in 1), dipyrido[3,2-d:2′,3′-f]quinoxaline (dpq in 2) and dipyrido[3,2-a:2′,3′-c]phenazine (dppz in 3), have been prepared, characterized and their photo-induced anaerobic DNA cleavage activity studied. The crystal structure of 1a as mixed ClO4− and PF6− salt of 1 shows a CoIIIN5S coordination geometry in which the pnt and phen showed N,S- and N,N-donor binding modes, respectively. The complexes exhibit Co(III)/Co(II) redox couple near −0.3 V (vs. SCE) in 20% DMF–Tris-HCl buffer having 0.1 M TBAP. The complexes show binding propensity to calf thymus DNA giving Kb values within 2.2 × 104–7.3 × 105 M−1. Thermal melting and viscosity data suggest DNA surface and/or groove binding of the complexes. The complexes show significant anaerobic DNA cleavage activity in red light under argon atmosphere possibly involving sulfide anion radical or thiyl radical species. The DNA cleavage reaction under aerobic medium in red light is found to involve both singlet oxygen and hydroxyl radical pathways. The dppz complex 3 shows non-specific BSA and lysozyme protein cleavage activity in UV-A light of 365 nm via both hydroxyl and singlet oxygen pathways. The dppz complex 3 exhibits photocytotoxicity in HeLa cervical cancer cells giving IC50 values of 767 nM and 19.38 μM in UV-A light of 365 nm and in the dark, respectively. A significant reduction of the dark toxicity of the dppz base (IC50 = 8.34 μM in dark) is observed on binding to the cobalt(III) center.
Starting Page	1807
Ending Page	1816
Page Count	10
File Format	HTM / HTML PDF
ISSN	14779226
Volume Number	39
Issue Number	7
Journal	Dalton Transactions
DOI	10.1039/b917860k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	TBAP BSA Pyridine Thiol Phenanthroline Quinoxaline Phenazine DNA Hexafluorophosphate Molecular geometry Redox Thymus Viscosity Argon Sulfide Ion Oxygen Singlet oxygen Hydroxyl radical Lysozyme Protein Ultraviolet HeLa Cervical cancer IC50 Cobalt
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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