NDLI: MRI relaxation properties of water-soluble apoferritin-encapsulated gadolinium oxide-hydroxide nanoparticles

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MRI relaxation properties of water-soluble apoferritin-encapsulated gadolinium oxide-hydroxide nanoparticles

Content Provider	Royal Society of Chemistry (RSC)
Author	Gálvez, Natividad Poletti, Giulio Sánchez, Purificación Marinone, Massimo Domínguez-Vera, José M. Corti, Maurizio Valero, Elsa Lascialfari, Alessandro
Copyright Year	2009
Abstract	We have prepared water-soluble gadolinium oxide nanoparticles that show potential as MRI contrast agents. The particles were built into the apoferritin cavity and have an average size of 5 nm. After seven days a loss of 5% of Gd was detected compared with the as-prepared samples; after that the Gd remained constant and stabilized inside the apoferritin, indicating that the apoferritin capsid acts as a Gd store, avoiding metal delivery and consequent toxicity. The NMR longitudinal and transverse relaxivities resulted about 10 and 70 times higher than the ones of clinically approved paramagnetic Gd-chelates, thus indicating the possible route for synthesizing a novel class of MRI contrast agents.
Starting Page	800
Ending Page	804
Page Count	5
File Format	HTM / HTML PDF
ISSN	14779226
Volume Number	0
Issue Number	5
Journal	Dalton Transactions
DOI	10.1039/b809645g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Gadolinium Magnetic resonance imaging Ferritin Capsid Nuclear magnetic resonance Paramagnetism
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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