NDLI: On the many roles of NH<sub>3</sub> ligands in mono- and multinuclear complexes of platinum

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On the many roles of NH₃ ligands in mono- and multinuclear complexes of platinum

Content Provider	Royal Society of Chemistry (RSC)
Author	Yin, Lu Lax, Patrick M. Krizanovic, Olga Fusch, Edda C. Lippert, Bernhard Lutterbeck, Matthias Holland, Lars Roitzsch, Michael Schürmann, Markus Miguel, Pablo J. Sanz
Copyright Year	2009
Abstract	The role of the NH3 ligands in the highly successful antitumour agents cisplatin and carboplatin is not fully understood. Suggestions that the ammonia ligands are involved in target recognition through hydrogen bond formation, e.g. with guanine-O6, have been questioned. Here, we review the roles and functions of NH3 ligands of cis-PtCl2(NH3)2 and likewise of its trans-isomer in complexes with model nucleobases as well as other N-heterocyclic ligands. Specifically, their roles in hydrogen bonding interactions with nucleobases as well as anions, the influence on acid–base properties of co-ligands, their involvement in condensation reactions, as well as a variety of displacement reactions will be examined. As a result, it can be stated that the ammonia ligands in cis- and trans-PtII(NH3)2 entities display additional features to those generally discussed in the last four decades since the discovery of the antitumour activity of cisplatin.
Starting Page	10774
Ending Page	10786
Page Count	13
File Format	HTM / HTML PDF
ISSN	14779226
Volume Number	0
Issue Number	48
Journal	Dalton Transactions
DOI	10.1039/b916537a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Ammonia Cisplatin Carboplatin Hydrogen bond
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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