NDLI: On the possibility of catalytic reduction of carbonyl moieties with tris(pentafluorophenyl)borane and H<sub>2</sub>: a computational study

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On the possibility of catalytic reduction of carbonyl moieties with tris(pentafluorophenyl)borane and H₂: a computational study

Content Provider	Royal Society of Chemistry (RSC)
Author	Nyhlén, Jonas Privalov, Timofei
Copyright Year	2009
Abstract	The study thoroughly examines the Gibbs free energy surfaces of a new mechanism for reduction of ketones/aldehydes by tris(pentafluorophenyl)borane (1) and H2. Key elements of the proposed mechanism are the proton and the hydride transfer steps similar to Stephan's catalytic reduction of imines by 1. The proton is transferred to the ketone/aldehyde in the process of H2 cleavage by the carbonyl–borane couple and the hydride is transferred in a nucleophilic attack on the carbonyl carbon by the hydridoborate in the ionic pair, [HOCRR’]+[HB(C6F5)3]−. The in solvent Gibbs free energy barriers of H2 splitting by adducts of B(C6F5)3 with acetone, acetophenone and benzaldehyde are predicted to be in the range of 24.5 ± 2.5 kcal mol−1, which corresponds to potential energy barriers in the range of 17.0 ± 2.0 kcal mol−1. Significantly lower barrier of H2activation is predicted in cases of bulky ketones such as 2,2,4,4-tetramethylpentan-3-one. With respect to the hydridoborate intermediate, the nucleophilic attack on the activated carbon is predicted to have a relatively low barrier for the sterically unhindered substrates, while this barrier is considerably higher for the sterically encumbered substrates. Since the formation of the hydridoborate intermediates is found to be endothermic, the transition state of the nucleophilic attack is the highest point of the computed energy profile for all tested substrates. Overall, according to in solvent density function calculations the proposed reduction of “compact” ketones/aldehydes by 1 and H2 is allowed both thermodynamically and kinetically at elevated temperature, but it is expected to be slower and more substrate specific than the corresponding reduction of imines.
Starting Page	5780
Ending Page	5786
Page Count	7
File Format	HTM / HTML PDF
ISSN	14779226
Volume Number	0
Issue Number	29
Journal	Dalton Transactions
DOI	10.1039/b905137f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Gibbs Stephan Gibbs free energy Tris(pentafluorophenyl)borane Hydrogen Hydride Ketone Aldehyde Carbonyl group Carbon Solvent Acetone Acetophenone Benzaldehyde Activated carbon Endothermic process
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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