NDLI: Stimuli-responsive organization of block copolymers on DNA nanotubes

Please wait, while we are loading the content...

Asymmetric Diels–Alder reaction of β,β-disubstituted enals and chromone-fused dienes: construction of collections with high molecular complexity and skeletal diversity

Ligand π-conjugation dictated intersystem crossing in phenyleneethynylene gold(i) complexes

Development of a solid phase synthesis strategy for soluble phosphoinositide analogues

Blended hydrogen atom abstraction and proton-coupled electron transfer mechanisms of closed-shell molecules

Formation of uncapped nanometre-sized metal particles by decomposition of metal carbonyls in carbon nanotubes

Highly branched Pt–Ni nanocrystals enclosed by stepped surface for methanol oxidation

Templated synthesis of nylon nucleic acids and characterization by nuclease digestion

Catalytically active supramolecular porphyrin boxes: acceleration of the methanolysis of phosphate triesters via a combination of increased local nucleophilicity and reactant encapsulation

Peptide-intercalated layered metal hydroxides: effect of peptide chain length and side chain functionality on structural, optical and magnetic properties

Microstructured objects produced by the supramolecular hierarchical assembly of an organic free radical gathering hydrophobic-amphiphilic characteristics

Self-organization of tetrapyrrole constituents to give a photoactive protocell

Copper(i)-catalyzed intramolecular [2 + 2] cycloaddition of 1,6-enyne-derived ketenimine: an efficient construction of strained and bridged 7-substituted-3-heterobicyclo[3.1.1]heptan-6-one

Stimuli-responsive organization of block copolymers on DNA nanotubes

Theoretical study of Pd(0)-catalyzed carbohalogenation of alkenes: mechanism and origins of reactivities and selectivities in alkyl halide reductive elimination from Pd(ii) species

Asymmetric catalytic epoxidation of α,β-unsaturated carbonyl compounds with hydrogen peroxide: Additive-free and wide substrate scope

Co-organisation of ionic liquids with amphiphilic diethanolamines: construction of 3D continuous ionic nanochannels through the induction of liquid–crystalline bicontinuous cubic phases

A complementary disk-shaped π electron donor–acceptor pair with high binding affinity

Structural characterization of zinc bicarbonate compounds relevant to the mechanism of action of carbonic anhydrase

Polyoxometalates adsorbed on metallic surfaces: immediate reduction of [SiW₁₂O₄₀]⁴⁻ on Ag(100)

Alternating layer addition approach to CdSe/CdS core/shell quantum dots with near-unity quantum yield and high on-time fractions

Antibiotic activity and target discovery of three-membered natural product-derived heterocycles in pathogenic bacteria

Chiral crystallization of aromatic helical foldamers via complementarities in shape and end functionalities

Patterned conductive nanostructures from reversible self-assembly of 1D coordination polymer

New light-harvesting roles of hot and forbidden carotenoid states in artificial photosynthetic constructs

A spontaneous gold(i)-azide alkyne cycloaddition reaction yields gold-peptide bioconjugates which overcome cisplatin resistance in a p53-mutant cancer cell line

Systems chemistry: logic gates based on the stimuli-responsive gel–sol transition of a crown ether-functionalized bis(urea) gelator

Platinum(iv) prodrugs entrapped within multiwalled carbon nanotubes: Selective release by chemical reduction and hydrophobicity reversal

Catalytic asymmetric α-amination of carboxylic acids using isothioureas

Role of the co-catalyst in the asymmetric coupling of racemic epoxides with CO₂ using multichiral Co(iii) complexes: product selectivity and enantioselectivity

Role of trace impurities in the photovoltaic performance of solution processed small-molecule bulk heterojunction solar cells

Lattice-imposed geometry in metal–organic frameworks: lacunary Zn₄O clusters in MOF-5 serve as tripodal chelating ligands for Ni²⁺

N-rich zeolite-like metal–organic framework with sodalite topology: high CO₂ uptake, selective gas adsorption and efficient drug delivery

Substituent effects in cation–π interactions. Recognition of tetramethylammonium chloride by uranyl-salophen receptors

Frustrated Lewis pair olefin addition reactions: P-, N-, C- and H-based nucleophilic additions to an olefin-tethered borane

β-Oligofurans

Driving selective aerobic oxidation of alkyl aromatics by sunlight on alcohol grafted metal hydroxides

Detection of carbohydrates using surface-assisted laser desorption/ionization mass spectrometry with HgTe nanostructures

Alkylated organic cages: from porous crystals to neat liquids

Supramolecular architectures for controlling slow magnetic relaxation in field-induced single-molecule magnets

Hindered biaryls by C–H coupling: bisoxazoline-Pd catalysis leading to enantioselective C–H coupling

Mesoporous g-C₃N₄ nanorods as multifunctional supports of ultrafine metal nanoparticles: hydrogen generation from water and reduction of nitrophenol with tandem catalysis in one step

Back cover

Chemical Science Vol - 3 Issue - 5

Chemical Science Vol - 3 Issue - 4

Chemical Science Vol - 3 Issue - 3

Chemical Science Vol - 3 Issue - 2

Chemical Science Vol -2

Chemical Science Vol -1

Stimuli-responsive organization of block copolymers on DNA nanotubes

Content Provider	Royal Society of Chemistry (RSC)
Author	McLaughlin, Christopher K. Hänni, Kevin D. Fakhoury, Johans Hamblin, Graham D. Rizis, Georgios Bazzi, Hassan S. Sleiman, Hanadi F. Nayak, Manoj K. Carneiro, Karina M. M.
Copyright Year	2012
Abstract	DNA nanotubes are an attractive class of materials that can be assembled with precise control over their size, shape, length and porosity, and can encapsulate and release materials in response to specific added molecules. In parallel, block copolymer assemblies can provide biocompatibility, stability, nuclease resistance, the ability to encapsulate small molecules, long-range assembly and numerous additional functionalities that can be tuned with subtle chemical modifications. Herein, we describe a new class of hybrid materials in which block copolymer assemblies are sequence-specifically and longitudinally positioned on robust DNA nanotubes constructed using rolling circle amplification. These materials are dynamic, allowing the polymer structures to be cleanly removed from the DNA nanotubes only when a specific DNA sequence is added, and creating a single-stranded form of these nanotubes. Specifically, we first describe the use of rolling circle amplification to create a long DNA strand containing a repeat sequence. This is used as a guide strand in a new method to construct robust nanotubes with a non-nicked backbone. We then synthesize polymer–DNA conjugates through on-column functionalization of a DNA strand with a polymer. These conjugates self-assemble into spherical aggregates, which then position themselves onto the DNA nanotubes using sequence-specific hybridization, creating a ‘striped' structure. The polymer aggregates can be cleanly lifted off the nanotubes using a strand displacement strategy, thus uncapping these DNA nanotubes. We also show that this longitudinal alignment of polymer aggregates on DNA nanotubes is general for a variety of DNA–block copolymers.
Starting Page	1980
Ending Page	1986
Page Count	7
File Format	HTM / HTML PDF
ISSN	20416520
Volume Number	3
Issue Number	6
Journal	Chemical Science
DOI	10.1039/c2sc01065h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	DNA Biocompatibility Polymer Porosity Copolymer Nuclease Rolling circle replication
Content Type	Text
Resource Type	Article
Subject	Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Stimuli-responsive organization of block copolymers on DNA nanotubes

A Cationic Smart Copolymer for DNA Binding

Syntheses of stimuli-responsive block copolymers of vinyl ethers with side oxyethylene groups by living cationic polymerization and their thermosensitive physical gelation

Stimuli-Responsive Block Copolymer-Based Assemblies for Cargo Delivery and Theranostic Applications

Novel Amphiphilic Block Copolymers for the Formation of Stimuli-Responsive Non-Lamellar Lipid Nanoparticles

Pe-Pcl Based Branched Polymer for Stimuli Responsive Delivery of Anticancer Drug Towards Cancerous Cell

Precise Control over the Rheological Behavior of Associating Stimuli-Responsive Block Copolymer Gels

Stimuli-Responsive Control over Self-Assembled Nanostructures in Sequence-Specific Functional Block Copolymers.

DNA Island Formation on Binary Block Copolymer Vesicles

Stimuli-responsive organization of block copolymers on DNA nanotubes

Similar Documents

Stimuli-responsive organization of block copolymers on DNA nanotubes

A Cationic Smart Copolymer for DNA Binding

Syntheses of stimuli-responsive block copolymers of vinyl ethers with side oxyethylene groups by living cationic polymerization and their thermosensitive physical gelation

Stimuli-Responsive Block Copolymer-Based Assemblies for Cargo Delivery and Theranostic Applications

Novel Amphiphilic Block Copolymers for the Formation of Stimuli-Responsive Non-Lamellar Lipid Nanoparticles

Pe-Pcl Based Branched Polymer for Stimuli Responsive Delivery of Anticancer Drug Towards Cancerous Cell

Precise Control over the Rheological Behavior of Associating Stimuli-Responsive Block Copolymer Gels

Stimuli-Responsive Control over Self-Assembled Nanostructures in Sequence-Specific Functional Block Copolymers.

DNA Island Formation on Binary Block Copolymer Vesicles

Stimuli-responsive organization of block copolymers on DNA nanotubes