NDLI: Stable luminescent iridium(iii) complexes with bis(N-heterocyclic carbene) ligands: photo-stability, excited state properties, visible-light-driven radical cyclization and CO<sub>2</sub> reduction, and cellular imaging

Content Provider	Royal Society of Chemistry (RSC)
Author	Chan, Sharon Lai-Fung Li, Kai Yang, Chen Che, Chi-Ming Zhou, Cong-Ying Zou, Taotao Guan, Xiangguo Yeung, Chi-Shun Mehmood, Faisal Wu, Yuan Lam, Tsz Lung Chung, Clive Yik-Sham
Copyright Year	2016
Abstract	A new class of cyclometalated Ir(III) complexes supported by various bidentate C-deprotonated (C^N) and cis-chelating bis(N-heterocyclic carbene) (bis-NHC) ligands has been synthesized. These complexes display strong emission in deaerated solutions at room temperature with photoluminescence quantum yields up to 89% and emission lifetimes up to 96 μs. A photo-stable complex containing C-deprotonated fluorenyl-substituted C^N shows no significant decomposition even upon irradiation for over 120 h by blue LEDs (12 W). These, together with the strong absorption in the visible region and rich photo-redox properties, allow the bis-NHC Ir(III) complexes to act as good photo-catalysts for reductive C–C bond formation from C(sp3/sp2)–Br bonds cleavage using visible-light irradiation (λ > 440 nm). A water-soluble complex with a glucose-functionalized bis-NHC ligand catalysed a visible-light-driven radical cyclization for the synthesis of pyrrolidine in aqueous media. Also, the bis-NHC Ir(III) complex in combination with a cobalt catalyst can catalyse the visible-light-driven CO2 reduction with excellent turnover numbers (>2400) and selectivity (CO over H2 in gas phase: >95%). Additionally, this series of bis-NHC Ir(III) complexes are found to localize in and stain endoplasmic reticulum (ER) of various cell lines with high selectivity, and exhibit high cytotoxicity towards cancer cells, revealing their potential uses as bioimaging and/or anti-cancer agents.
Starting Page	3123
Ending Page	3136
Page Count	14
File Format	HTM / HTML PDF
ISSN	20416520
Volume Number	7
Issue Number	5
Journal	Chemical Science
DOI	10.1039/c5sc04458h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Persistent carbene Ligand Photoluminescence Cytotoxicity CO Cobalt Radical cyclization Quantum Denticity Covalent bond Pyrrolidine Endoplasmic reticulum Cancer
Content Type	Text
Resource Type	Article
Subject	Chemistry

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