NDLI: Amplifying undetectable NMR signals to study host

Please wait, while we are loading the content...

Resolving the α-glycosidic linkage of arginine-rhamnosylated translation elongation factor P triggers generation of the first Arg^Rha specific antibody

C–H functionalization of amines with aryl halides by nickel-photoredox catalysis

Converting disulfide bridges in native peptides to stable methylene thioacetals

Emissive nanoparticles from pyridinium-substituted tetraphenylethylene salts: imaging and selective cytotoxicity towards cancer cells in vitro and in vivo by varying counter anions

Competition between drum and quasi-planar structures in RhB₁₈⁻: motifs for metallo-boronanotubes and metallo-borophenes

The impact of grafted surface defects and their controlled removal on supramolecular self-assembly

Dioxygen insertion into the gold(i)–hydride bond: spin orbit coupling effects in the spotlight for oxidative addition

Synthesis of malhamensilipin A exploiting iterative epoxidation/chlorination: experimental and computational analysis of epoxide-derived chloronium ions

Intermolecular oxidative decarbonylative [2 + 2 + 2] carbocyclization of N-(2-ethynylaryl)acrylamides with tertiary and secondary alkyl aldehydes involving C(sp³)–H functionalization

A genetically encoded multifunctional unnatural amino acid for versatile protein manipulations in living cells

Directly probing spin dynamics in a molecular magnet with femtosecond time-resolution

Ru–protein–Co biohybrids designed for solar hydrogen production: understanding electron transfer pathways related to photocatalytic function

Understanding and predicting the potency of ROS-based enzyme inhibitors, exemplified by naphthoquinones and ubiquitin specific protease-2

Photochemical pump and NMR probe to monitor the formation and kinetics of hyperpolarized metal dihydrides

Competitive method-based electrochemiluminescent assay with protein–nucleotide conversion for ratio detection to efficiently monitor the drug resistance of cancer cells

Competitive coordination strategy for the synthesis of hierarchical-pore metal–organic framework nanostructures

Inside back cover

Back cover

Chemical Science Vol - 7 Issue - 9

Chemical Science Vol - 7 Issue - 8

Chemical Science Vol - 7 Issue - 7

Chemical Science Vol - 7 Issue - 6

Chemical Science Vol - 7 Issue - 5

Chemical Science Vol - 7 Issue - 4

Chemical Science Vol - 7 Issue - 3

Chemical Science Vol - 7 Issue - 2

Chemical Science Vol -6

Chemical Science Vol -5

Chemical Science Vol -4

Chemical Science Vol -3

Chemical Science Vol -2

Chemical Science Vol -1

Amplifying undetectable NMR signals to study host–guest interactions and exchange

Content Provider	Royal Society of Chemistry (RSC)
Author	Bar-Shir, Amnon Iron, Mark A. Avram, Liat
Copyright Year	2016
Abstract	The characteristics of host–guest systems, such as molecular recognition, complexation, encapsulation, guest composition, and dynamic exchange, are manifested by changes in the chemical shifts (Δω) in the NMR spectrum. However, in cases where NMR signals cannot be detected, due to low concentrations, poor solubility, or relatively fast exchange, an alternative is needed. Here, we show that by using the magnetization transfer (MT) method, the undetectable NMR signals of host–guest assemblies can be amplified by two orders of magnitude. It is shown that the binding kinetics characteristics of a fluorinated guest and cucurbit[n]uril (CB[n]) hosts in aqueous solutions determine the NMR signal amplification of host–guest assemblies. In addition, by using the MT technique within the 19F-NMR framework, one can detect μM concentrations of the complex and study the effect of different solutes on the resulting host–guest system. The results expand the “NMR toolbox” available to explore a wider range of dynamic host–guest systems in which NMR signals cannot be detected.
Starting Page	6905
Ending Page	6909
Page Count	5
File Format	HTM / HTML PDF
ISSN	20416520
Volume Number	7
Issue Number	12
Journal	Chemical Science
DOI	10.1039/c6sc04083g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Visual cortex Citizens band radio Cucurbitaceae Molecular recognition Treatment as prevention Nuclear magnetic resonance
Content Type	Text
Resource Type	Article
Subject	Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Host-Guest Exchange of Viologen Guests in Porphyrin Cage Compounds as Studied by Selective Exchange Spectroscopy (1D EXSY) NMR.

Probing Guest Geometry and Dynamics through Host–Guest Interactions

Hyperbranched supramolecular polymer constructed from twisted cucurbit[14]uril and porphyrin via host–guest interactions

High-affinity host–guest complex of cucurbit[7]uril with a bis(thiazolium) salt

Coupling of molecular motions through non-bonding interactions: 13C NMR spin–lattice relaxation studies of a host–guest complex

Host-Guest Chemistry of Tolbutamide

Full paper host-guest chemistry of tolbutamide (2006).

Xenon Host-Guest Interactions for Applications in NMR and MRI

Estimation of Enantiomeric Excess Based on Rapid Host–Guest Exchange

Amplifying undetectable NMR signals to study host–guest interactions and exchange

Similar Documents

Host-Guest Exchange of Viologen Guests in Porphyrin Cage Compounds as Studied by Selective Exchange Spectroscopy (1D EXSY) NMR.

Probing Guest Geometry and Dynamics through Host–Guest Interactions

Hyperbranched supramolecular polymer constructed from twisted cucurbit[14]uril and porphyrin via host–guest interactions

High-affinity host–guest complex of cucurbit[7]uril with a bis(thiazolium) salt

Coupling of molecular motions through non-bonding interactions: 13C NMR spin–lattice relaxation studies of a host–guest complex

Host-Guest Chemistry of Tolbutamide

Full paper host-guest chemistry of tolbutamide (2006).

Xenon Host-Guest Interactions for Applications in NMR and MRI

Estimation of Enantiomeric Excess Based on Rapid Host–Guest Exchange

Amplifying undetectable NMR signals to study host–guest interactions and exchange