NDLI: NKT cell-dependent glycolipid–peptide vaccines with potent anti-tumour activity

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NKT cell-dependent glycolipid–peptide vaccines with potent anti-tumour activity

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NKT cell-dependent glycolipid–peptide vaccines with potent anti-tumour activity

Content Provider	Royal Society of Chemistry (RSC)
Author	Weinkove, Robert Painter, Gavin F. Swinerd, Gene W. Tang, Ching-wen Hermans, Ian F. Compton, Benjamin J. Gasser, Olivier Anderson, Regan J. Harris, Paul Larsen, David S. Kowalczyk, Renata Brimble, Margaret A. Authier-Hall, Astrid Hayman, Colin M.
Copyright Year	2015
Abstract	It is known that T cells can eliminate tumour cells through recognition of unique or aberrantly expressed antigens presented as peptide epitopes by major histocompatibility complex (MHC) molecules on the tumour cell surface. With recent advances in defining tumour-associated antigens, it should now be possible to devise therapeutic vaccines that expand specific populations of anti-tumour T cells. However there remains a need to develop simpler efficacious synthetic vaccines that possess clinical utility. We present here the synthesis and analysis of vaccines based on conjugation of MHC-binding peptide epitopes to α-galactosylceramide, a glycolipid presented by the nonpolymorphic antigen-presenting molecule CD1d to provoke the stimulatory activity of type I natural killer T (NKT) cells. The chemical design incorporates an enzymatically cleavable linker that effects controlled release of the active components in vivo. Chemical and biological analysis of different linkages with different enzymatic targets enabled selection of a synthetic vaccine construct with potent therapeutic anti-tumour activity in mice, and marked in vitro activity in human blood.
Starting Page	5120
Ending Page	5127
Page Count	8
File Format	HTM / HTML PDF
ISSN	20416520
Volume Number	6
Issue Number	9
Journal	Chemical Science
DOI	10.1039/c4sc03599b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Synthetic vaccine CD1D Peptide Histocompatibility Glycolipid
Content Type	Text
Resource Type	Article
Subject	Chemistry

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CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides

A potent adjuvant effect of a CD1d-binding NKT cell ligand in human immune system mice

Vivo identification of glycolipid antigen-specific t cells using fluorescent cd1d tetramers (2000).

Glycolipid activators of invariant NKT cells as vaccine adjuvants

Glycolipid-peptide conjugate vaccines elicit CD8⁺ T-cell responses and prevent breast cancer metastasis.

Interdependency of MHC Class II/Self-Peptide and CD1d/Self-Glycolipid Presentation by TNF-Matured Dendritic Cells for Protection from Autoimmunity

Glycolipids and phospholipids as natural CD1d-binding NKT cell ligands

A role for cd1d-restricted nkt cells in injury-associated t cell suppression.

A role for cd1d-restricted nkt cells in injury-associated t cell suppression (2003).

NKT cell-dependent glycolipid–peptide vaccines with potent anti-tumour activity

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