NDLI: Ultra-sensitive pH control of supramolecular polymers and hydrogels: p<i>K</i><sub>a</sub> matching of biomimetic monomers

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Ultra-sensitive pH control of supramolecular polymers and hydrogels: pK_a matching of biomimetic monomers

Content Provider	Royal Society of Chemistry (RSC)
Author	Avirah, R. R. Cafferty, B. J. Hud, N. V. Schuster, G. B.
Copyright Year	2014
Abstract	Achieving self-assembly in water with small molecules that disassemble in response to minimal changes in environmental conditions is important for the development of many promising materials. We report the most sensitive possible pH control of a supramolecular polymer assembly – demonstrated with hydrogel-forming monomers that mimic nucleic acid base pairing. Bidirectional pH-responsive supramolecular polymers are formed upon the self-assembly of three monomers with two pKa-matched recognition units (one acidic and one basic). These supramolecular assemblies are most stable when the pH equals the pKa of the monomers, but disassemble in response to small pH changes near neutrality (exhibiting the theoretical limit for pH-dependent stability). At pH 7 a hydrogel forms in solutions that are 0.7% by weight in monomer, however, the hydrogel dissolves at pH 6 and pH 8. Additionally, we show that hydrogel stability is finely tuned by employing monomer mixtures that frustrate formation of insoluble aggregates. These results illustrate the advantages of using pKa-matched recognition elements and polymer heterogeneity in the development of responsive materials. Finally, these same recognition elements have recently been proposed as possible ancestors of the current bases of RNA. In this context, the assemblies described here might also provide clues to how the first genetic polymers were driven between states of base pairing and non-base pairing by periodic changes in environmental pH.
Starting Page	4681
Ending Page	4686
Page Count	6
File Format	HTM / HTML PDF
ISSN	20416520
Volume Number	5
Issue Number	12
Journal	Chemical Science
DOI	10.1039/c4sc02182g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Central Cross-Island Highway Self-assembly Acid RNA Acid dissociation constant PH Polymer Monomer Gel
Content Type	Text
Resource Type	Article
Subject	Chemistry

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