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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Ameer, Guillermo A. Wang, Ying Kibbe, Melina R. |
| Copyright Year | 2013 |
| Abstract | The delivery of nitric oxide (NO) has important applications in medicine, especially for procedures that involve the vasculature. We report photo-curable biodegradable poly(diol citrate) elastomers capable of slow release of NO. A methacrylated poly(diol citrate) macromonomer was prepared by polycondensation of citric acid with 1,8-octanediol or 1,12-dodecanediol followed by functionalization with 2-aminoethyl methacrylate. A miscible NO donor, diazeniumdiolated N,N-diethyldiethylenetriamine, was synthesized and incorporated into the polymer matrix. An elastomeric network was obtained via photo-polymerization of macromonomers upon UV irradiation within three minutes. Films and tubes of the NO-releasing crosslinked macromonomers exhibited strong tensile strength and radial compressive strength, respectively. They also exhibited cell compatibility and biodegradability in vitro. Sustained NO release under physiological conditions was achieved for at least one week. NO release enhanced the proliferation of human umbilical vein endothelial cells but inhibited the proliferation of human aortic smooth muscle cells. Photo-polymerizable NO-releasing materials provide a new approach for the localized and sustained delivery of NO to treat thrombosis and restenosis in the vasculature. |
| Starting Page | 625 |
| Ending Page | 632 |
| Page Count | 8 |
| File Format | HTM / HTML PDF |
| ISSN | 20474830 |
| Volume Number | 1 |
| Issue Number | 6 |
| Journal | Biomaterials Science |
| DOI | 10.1039/c3bm00169e |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Biodegradation Diol Acid Condensation reaction Macromonomer Ultimate tensile strength Polymer Smooth muscle tissue Compressive strength 1,8-Octanediol Thrombosis Citric acid Endothelium Restenosis Nitric oxide Miscibility Extracellular matrix Aorta Umbilical vein |
| Content Type | Text |
| Resource Type | Article |
| Subject | Materials Science Biomedical Engineering |
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