NDLI: Mustard-inspired delivery shuttle for enhanced blood–brain barrier penetration and effective drug delivery in glioma therapy

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Mustard-inspired delivery shuttle for enhanced blood–brain barrier penetration and effective drug delivery in glioma therapy

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Biomaterials Science Vol - 5 Issue - 4

Biomaterials Science Vol - 5 Issue - 3

Biomaterials Science Vol - 5 Issue - 2

Biomaterials Science Vol - 5 Issue - 1

Biomaterials Science Vol -4

Biomaterials Science Vol -3

Biomaterials Science Vol -2

Biomaterials Science Vol -1

Mustard-inspired delivery shuttle for enhanced blood–brain barrier penetration and effective drug delivery in glioma therapy

Content Provider	Royal Society of Chemistry (RSC)
Author	Tong, Gangsheng Wang, Nan Zhu, Xinyuan Lv, Mingming Jin, Xin Sun, Pei
Copyright Year	2017
Abstract	Effective penetration through the blood–brain barrier (BBB) remains a challenge for the treatment of many brain diseases. In this study, a small molecule, sinapic acid (SA), extracted from mustard, was selected as a novel bioinspired BBB-permeable ligand for efficient drug delivery in glioma treatment. SA was conjugated on the surface of zwitterionic polymer poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-encapsulated bovine serum albumin (BSA)-based nanoparticles, yielding nBSA-SA. The PMPC shell serves as a protective layer to prolong the in vivo blood circulation time with a better chance to cross the BBB. Furthermore, temozolomide (TMZ), which can be loaded onto the nanoparticles via electrostatic interactions with acrylic acid (AA) to generate AA-nBSA-SA-TMZ, was applied as an excellent chemotherapeutic drug for glioma therapy. The obtained nanoparticles with a distinct size show great BBB permeability. Through the mechanism study, it was found that the cell internalization of the SA-conjugated nanoparticles is an energy-dependent process with only transient disruption of the BBB. The biological evaluation results unambiguously suggest that drug-loaded nanoparticles can lead to strong apoptosis on the tumor site and increase the median survival time of glioma-bearing mice. Overall, this novel BBB-permeable ligand SA paves the way for the delivery of cargo into the brain and provides a powerful nanoplatform for glioma therapy via intravenous administration.
Starting Page	1041
Ending Page	1050
Page Count	10
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	5
Issue Number	5
Journal	Biomaterials Science
DOI	10.1039/c7bm00133a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	TMZ Bovine serum albumin Cell membrane Ligand Sulfur mustard Blood\u2013brain barrier Polymer Drug delivery BSA Glioma Carboxylic acid Temozolomide Apoptosis
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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