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Biomaterials Science Vol - 5 Issue - 2

Biomaterials Science Vol - 5 Issue - 1

Biomaterials Science Vol -4

Biomaterials Science Vol -3

Biomaterials Science Vol -2

Biomaterials Science Vol -1

Backbone-modified oligonucleotides for tuning the cellular uptake behaviour of spherical nucleic acids

Content Provider	Royal Society of Chemistry (RSC)
Author	Kim, Kyoung-Ran Ahn, Dae-Ro Song, Woo Chul Lee, Kyung Eun Park, Miri
Copyright Year	2017
Abstract	Spherical nucleic acids (SNAs) are spherically arranged oligonucleotides on core inorganic nanoparticles and have great potential for intracellular delivery of bioactive molecules, since they have been found to be internalized into mammalian cells. Understanding the factors that influence the cellular uptake of SNAs would be beneficial to design SNAs with novel uptake properties. We here report the effect of the sugar backbone type of the oligonucleotides on the cellular internalization of SNAs. After the preparation of SNAs with the oligonucleotides of five different sugar backbones, we analyze the cellular uptake efficiency quantitatively by flow cytometry and inductively coupled plasma mass spectrometry (ICP-MS). The data reveal that the uptake efficiencies and the uptake mechanisms significantly rely on the backbone type. These results suggest that the backbone modification can provide a unique handle to tune the cellular uptake behavior of SNAs.
Starting Page	412
Ending Page	416
Page Count	5
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	5
Issue Number	3
Journal	Biomaterials Science
DOI	10.1039/c6bm00792a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Flow cytometry Carbohydrate Inductively coupled plasma mass spectrometry
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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