NDLI: Effects of ovalbumin protein nanoparticle vaccine size and coating on dendritic cell processing

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Biomaterials Science Vol -5

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Insight into the interactions between nanoparticles and cells

Noninvasive photothermal cancer therapy nanoplatforms via integrating nanomaterials and functional polymers

Biorthogonal click chemistry on poly(lactic-co-glycolic acid)-polymeric particles

Electrochemical manipulation of cell populations supported by biodegradable polymeric nanosheets for cell transplantation therapy

Effects of ovalbumin protein nanoparticle vaccine size and coating on dendritic cell processing

Thermoresponsive microgels containing trehalose as soft matrices for 3D cell culture

Ultrasmall silver nanoclusters: Highly efficient antibacterial activity and their mechanisms

Multifunctional PEI-entrapped gold nanoparticles enable efficient delivery of therapeutic siRNA into glioblastoma cells

Interactions between circulating nanoengineered polymer particles and extracellular matrix components in vitro

Intracellular GSH-activated galactoside photosensitizers for targeted photodynamic therapy and chemotherapy

An injectable collagen/poly(γ-glutamic acid) hydrogel as a scaffold of stem cells and α-lipoic acid for enhanced protection against renal dysfunction

ATB^0,+ transporter-mediated targeting delivery to human lung cancer cells via aspartate-modified docetaxel-loading stealth liposomes

Polyaspartamide-based graft copolymers encapsulating iron oxide nanoparticles for imaging and fluorescence labelling of immune cells

NIR imaging-guided combined photodynamic therapy and chemotherapy by a pH-responsive amphiphilic polypeptide prodrug

An in situ poly(carboxybetaine) hydrogel for tissue engineering applications

Comparison of nanomedicine-based chemotherapy, photodynamic therapy and photothermal therapy using reduced graphene oxide for the model system

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Biomaterials Science Vol - 5 Issue - 1

Biomaterials Science Vol -4

Biomaterials Science Vol -3

Biomaterials Science Vol -2

Biomaterials Science Vol -1

Effects of ovalbumin protein nanoparticle vaccine size and coating on dendritic cell processing

Content Provider	Royal Society of Chemistry (RSC)
Author	Chang, Timothy Z. Stadmiller, Samantha S. Staskevicius, Erika Champion, Julie A.
Copyright Year	2017
Abstract	Nanoparticle vaccine delivery platforms are a promising technology for enhancing vaccine immunogenicity. Protein nanoparticles (PNPs), made entirely from antigen, have been shown to induce protective immune responses against influenza. However, the fundamental mechanisms by which PNPs enhance component protein immunogenicity are not understood. Here, we investigate the role of size and coating of model ovalbumin (OVA) PNPs on particle uptake and trafficking, as well as on inflammation and maturation factor expression in dendritic cells (DCs) in vitro. OVA PNPs enhance antigen uptake in a size-independent manner, and experience attenuated endosomal acidification as compared to soluble OVA. OVA PNPs also trigger Fc receptor upregulation. Expression of cytokines IL-1β and TNF-α were PNP size- and coating-dependent, with small (∼270 nm) nanoparticles triggering greater inflammatory cytokine production than large (∼560 nm) particles. IL-1β expression by DCs in response to PNP stimulation implies activation of the inflammasome, a pathway known to be activated by certain types of nanoparticulate adjuvants. The attenuated acidification and pro-inflammatory profile generated by PNPs in DCs demonstrate that physical biomaterial properties can modulate dendritic cell-mediated antigen processing and adjuvancy. In addition to nanoparticles’ enhancement of DC antigen uptake, our work suggests that vaccine nanoparticle size and coating are uptake-independent modulators of immunogenicity.
Starting Page	223
Ending Page	233
Page Count	11
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	5
Issue Number	2
Journal	Biomaterials Science
DOI	10.1039/c6bm00500d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Ovalbumin Dendritic cell Nanoparticle Cytokine Antigen processing Orthomyxoviridae Vaccine Original video animation Inflammation Inflammasome Protein Antigen Interleukin-1 family Tumor necrosis factor alpha PNP Fc receptor Immunogenicity Biomaterial
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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Chemically modified inulin microparticles serving dual function as a protein antigen delivery vehicle and immunostimulatory adjuvant

Hydrolysates of egg white proteins modulate T- and B-cell responses in mitogen-stimulated murine cells

Cytokine-regulated expression and inhibitory function of FcgammaRIIB1 and -B2 receptors in human dendritic cells.

Modulation of antiviral immune responses by exogenous cytokines: effects of tumour necrosis factor-alpha, interleukin-1 alpha, interleukin-2 and interferon gamma on the immunogenicity of an inactivated rabies vaccine (1994).

Viral Oncolysis: Increased Immunogenicity of Host Cell Antigen Associated with Influenza Virus

Association of C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 with chronic kidney disease

CD200 modulates macrophage cytokine secretion and phagocytosis in response to poly(lactic-co-glycolic acid) microparticles and films

Prostaglandin E2 and Tumor Necrosis Factor α Cooperate to Activate Human Dendritic Cells: Synergistic Activation of Interleukin 12 Production

Inducing Tumor Immunity through the Selective Engagement of Activating Fc � Receptors on Dendritic Cells

Effects of ovalbumin protein nanoparticle vaccine size and coating on dendritic cell processing

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Chemically modified inulin microparticles serving dual function as a protein antigen delivery vehicle and immunostimulatory adjuvant

Hydrolysates of egg white proteins modulate T- and B-cell responses in mitogen-stimulated murine cells

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Effects of ovalbumin protein nanoparticle vaccine size and coating on dendritic cell processing