NDLI: The effect of silicate ions on proliferation, osteogenic differentiation and cell signalling pathways (WNT and SHH) of bone marrow stromal cells

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Biomaterials Science Vol - 1 Issue - 3

Biomaterials Science Vol - 1 Issue - 2

The effect of silicate ions on proliferation, osteogenic differentiation and cell signalling pathways (WNT and SHH) of bone marrow stromal cells

Content Provider	Royal Society of Chemistry (RSC)
Author	Han, Pingping Wu, Chengtie Xiao, Yin
Copyright Year	2013
Abstract	Silicon (Si) is a trace element, which plays an important role in human bone growth. Si has been incorporated into biomaterials for bone regeneration in order to improve their osteogenic potential, both in vitro and in vivo. Little is known, however, as to how Si ions elicit their biological response on bone-forming cells. The aim of this study was to investigate the effect of Si ions on the proliferation, differentiation, bone-related gene expression and cell signalling pathways of bone marrow stromal cells (BMSCs) by comparing the BMSC responses to different concentrations of NaCl and Na2SiO3, while taking into account and excluding the effect of Na ions. Our study showed that Si ions at a concentration of 0.625 mM significantly enhanced the proliferation, mineralization nodule formation, bone-related gene expression (OCN, OPN and ALP) and bone matrix proteins (ALP and OPN) of BMSCs. Furthermore, Si ions at 0.625 mM could counteract the effect of the WNT inhibitor (W.I.) cardamonin on the osteogenic genes expression, (OPN, OCN and ALP), WNT and SHH signalling pathway-related genes in BMSCs. These results suggest that Si ions by themselves play an important role in regulating the proliferation and osteogenic differentiation of BMSCs, with the involvement of WNT and SHH signalling pathways. Our study provides evidence to explain possible molecular mechanisms whereby Si ions released from Si-containing biomaterials can acquire enhanced bioactivity at desired concentration.
Starting Page	379
Ending Page	392
Page Count	14
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	1
Issue Number	4
Journal	Biomaterials Science
DOI	10.1039/c2bm00108j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Trace element Gene Bone marrow Nippon Telegraph and Telephone Enzyme inhibitor Extracellular matrix Silicon Biomaterial OCN Bone OPN Cell signaling
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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