NDLI: Sustained release of active chemotherapeutics from injectable-solid β-hairpin peptide hydrogel

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Articular cartilage: from formation to tissue engineering

Utilizing stem cells for three-dimensional neural tissue engineering

Design of nanomaterial based systems for novel vaccine development

Recent advances in mesoporous silica nanoparticles for antitumor therapy: our contribution

Mesomeric configuration makes polyleucine micelle an optimal nanocarrier

Regulating VEGF signaling in platelet concentrates via specific VEGF sequestering

Calcium phosphate-based organic–inorganic hybrid nanocarriers with pH-responsive on/off switch for photodynamic therapy

Sustained release of active chemotherapeutics from injectable-solid β-hairpin peptide hydrogel

Targeted delivery of microRNA-126 to vascular endothelial cells via REDV peptide modified PEG-trimethyl chitosan

A biocompatible cobaltporphyrin-based complex micelle constructed via supramolecular assembly for oxygen transfer

Regulation of breast cancer cell behaviours by the physical microenvironment constructed via projection microstereolithography

Cationic polycarbonate-grafted superparamagnetic nanoparticles with synergistic dual-modality antimicrobial activity

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Sustained release of active chemotherapeutics from injectable-solid β-hairpin peptide hydrogel

Content Provider	Royal Society of Chemistry (RSC)
Author	Litan, Alisa Pochan, Darrin J. Stewart, Brandon Langhans, Sigrid A. Lee, Seung Joon Sun, Jessie E. P. Schneider, Joel P.
Copyright Year	2016
Abstract	MAX8 β-hairpin peptide hydrogel is a solid, preformed gel that can be syringe injected due to shear-thinning properties and can recover solid gel properties immediately after injection. This behavior makes the hydrogel an excellent candidate as a local drug delivery vehicle. In this study, vincristine, a hydrophobic and commonly used chemotherapeutic, is encapsulated within MAX8 hydrogel and shown to release constantly over the course of one month. Vincristine was observed to be cytotoxic in vitro at picomolar to nanomolar concentrations. The amounts of drug released from the hydrogels over the entire time-course were in this concentration range. After encapsulation, release of vincristine from the hydrogel was observed for four weeks. Further characterization showed the vincristine released during the 28 days remained biologically active, well beyond its half-life in bulk aqueous solution. This study shows that vincristine-loaded MAX8 hydrogels are excellent candidates as drug delivery vehicles, through sustained, low, local and effective release of vincristine to a specific target. Oscillatory rheology was employed to show that the shear-thinning and re-healing, injectable-solid properties that make MAX8 a desirable drug delivery vehicle are unaffected by vincristine encapsulation. Rheology measurements also were used to monitor hydrogel nanostructure before and after drug encapsulation.
Starting Page	839
Ending Page	848
Page Count	10
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	4
Issue Number	5
Journal	Biomaterials Science
DOI	10.1039/c5bm00538h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Biological half-life Delivery (commerce) Rheology Cytotoxicity Drug delivery Nanostructure Hydrophobe Peptide Vincristine Shear thinning Gel
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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