NDLI: Functional hydroxyapatite bioceramics with excellent osteoconductivity and stern-interface induced antibacterial ability

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Functional hydroxyapatite bioceramics with excellent osteoconductivity and stern-interface induced antibacterial ability

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Biomaterials Science Vol - 4 Issue - 3

Biomaterials Science Vol - 4 Issue - 2

Biomaterials Science Vol -3

Biomaterials Science Vol -2

Biomaterials Science Vol -1

Functional hydroxyapatite bioceramics with excellent osteoconductivity and stern-interface induced antibacterial ability

Content Provider	Royal Society of Chemistry (RSC)
Author	Wang, Liping Zhu, Yingchun Shao, Yiran Shi, Chao Gao, Jianyong Wang, Dalin Wang, Ming
Copyright Year	2016
Abstract	The biocompatibility and antibacterial properties of hydroxyapatite (HAp) bioceramics are crucial in medical applications. However, it is still a challenge to control HAp with antibacterial ability while maintaining other biological properties in the development of bioactive bone implants. Herein, we report functional silver ion substituted HAp bioceramics with excellent osteoconductivity and efficient antibacterial activity and propose a stern-interface induced antibacterial mechanism of such bioactive ceramics. In this antibacterial process, the concentration of Ag+ at the stern-interface of Ag/HAp bioceramics is nearly 5 times higher than that in the bulk solution due to the trace dopant Ag+ enrichment in the stern layer of the electric double layer at the negatively charged surface of Ag/HAp bioceramics. Trace Ag-doping in HAp induces a positive shift of zeta potential and increase of hydrophilicity, which may help inhibit bacterial proliferation. The positive osteoblast adhesion, proliferation and differentiation of ultra-trace doped Ag/HAp are also demonstrated through actin cytoskeleton staining, MTT and alkaline phosphatase (ALP) activity assays. This work may enlighten us on the artificial design of novel smart anti-infective bone grafts using ultra-trace functional elements and also suggest its potential applications in orthopedic surgery and bone osseointegration.
Starting Page	699
Ending Page	710
Page Count	12
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	4
Issue Number	4
Journal	Biomaterials Science
DOI	10.1039/c6bm00009f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Alkaline phosphatase Osseointegration Stern Ion MTT Orthopedic surgery Zeta potential Actin Hydroxylapatite Dopant Osteoblast Biocompatibility Cytoskeleton Bone Hydrophile
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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excellent biocompatibility and osteoconductivity as well as close similarity to human bone structure,

Functional hydroxyapatite bioceramics with excellent osteoconductivity and stern-interface induced antibacterial ability

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