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Supra-molecular assembly of a lumican-derived peptide amphiphile enhances its collagen-stimulating activity

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Biomaterials Science Vol -3

Biomaterials Science Vol -2

Biomaterials Science Vol -1

Supra-molecular assembly of a lumican-derived peptide amphiphile enhances its collagen-stimulating activity

Content Provider	Royal Society of Chemistry (RSC)
Author	Dehsorkhi, Ashkan Hamley, Ian W. Walter, Merlin N. M. Connon, Che J.
Copyright Year	2016
Abstract	C16-YEALRVANEVTLN, a peptide amphiphile (PA) incorporating a biologically active amino acid sequence found in lumican, has been examined for its influence upon collagen synthesis by human corneal fibroblasts in vitro, and the roles of supra-molecular assembly and activin receptor-like kinase ALK receptor signaling in this effect were assessed. Cell viability was monitored using the Alamar blue assay, and collagen synthesis was assessed using Sirius red. The role of ALK signaling was studied by receptor inhibition. Cultured human corneal fibroblasts synthesized significantly greater amounts of collagen in the presence of the PA over both 7-day and 21-day periods. The aggregation of the PA to form nanotapes resulted in a notable enhancement in this activity, with an approximately two-fold increase in collagen production per cell. This increase was reduced by the addition of an ALK inhibitor. The data presented reveal a stimulatory effect upon collagen synthesis by the primary cells of the corneal stroma, and demonstrate a direct influence of supra-molecular assembly of the PA upon the cellular response observed. The effects of PA upon fibroblasts were dependent upon ALK receptor function. These findings elucidate the role of self-assembled nanostructures in the biological activity of peptide amphiphiles, and support the potential use of a self-assembling lumican derived PA as a novel biomaterial, intended to promote collagen deposition for wound repair and tissue engineering purposes.
Starting Page	346
Ending Page	354
Page Count	9
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	4
Issue Number	2
Journal	Biomaterials Science
DOI	10.1039/c5bm00428d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Alamar Peptide amphiphile ALK inhibitor Cell surface receptor Tissue engineering Activin and inhibin Supramolecular chemistry Stroma of cornea Sirius Carboxylic acid Kinase Collagen Amphiphile Biomaterial Peptide Anaplastic lymphoma kinase
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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Supra-molecular assembly of a lumican-derived peptide amphiphile enhances its collagen-stimulating activity† †Electronic supplementary information (ESI) available: DETAILS. See DOI: 10.1039/c5bm00428d Click here for additional data file.

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Supra-molecular assembly of a lumican-derived peptide amphiphile enhances its collagen-stimulating activity

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Supra-molecular assembly of a lumican-derived peptide amphiphile enhances its collagen-stimulating activity† †Electronic supplementary information (ESI) available: DETAILS. See DOI: 10.1039/c5bm00428d Click here for additional data file.

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Supra-molecular assembly of a lumican-derived peptide amphiphile enhances its collagen-stimulating activity