NDLI: The effect of photoinitiators on intracellular AKT signaling pathway in tissue engineering application

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The effect of photoinitiators on intracellular AKT signaling pathway in tissue engineering application

Content Provider	Royal Society of Chemistry (RSC)
Author	Yang, Hu Xu, Leyuan Sheybani, Natasha Yeudall, W. Andrew
Copyright Year	2015
Abstract	Free-radical photopolymerization initiated by photoinitiators is an important method to make tissue engineering scaffolds. To advance understanding of photoinitiator cytocompatibility, we examined three photoinitiators including 2,2-dimethoxy-2-phenylacetophenone (DMPA), Irgacure 2959 (I-2959), and eosin Y photoinitiating system (EY) in terms of their effects on the viability of HN4 cells and expression levels of intracellular AKT and its phosphorylated form p-AKT. Our results show that the photoinitiators and their UV-exposed counterparts affect intracellular AKT signaling, which can be used in conjunction with cell viability for cytocompatibility assessment of photoinitiators.
Starting Page	250
Ending Page	255
Page Count	6
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	3
Issue Number	2
Journal	Biomaterials Science
DOI	10.1039/c4bm00245h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Protein kinase B Tissue engineering Polymerization 2,2-Dimethoxy-2-phenylacetophenone Eosin Y Photoinitiator
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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