NDLI: Lithium release from β-tricalcium phosphate inducing cementogenic and osteogenic differentiation of both hPDLCs and hBMSCs

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Lithium release from β-tricalcium phosphate inducing cementogenic and osteogenic differentiation of both hPDLCs and hBMSCs

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Biomaterials Science Vol - 2 Issue - 8

Biomaterials Science Vol - 2 Issue - 7

Biomaterials Science Vol - 2 Issue - 6

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Biomaterials Science Vol - 2 Issue - 2

Biomaterials Science Vol -1

Lithium release from β-tricalcium phosphate inducing cementogenic and osteogenic differentiation of both hPDLCs and hBMSCs

Content Provider	Royal Society of Chemistry (RSC)
Author	Han, Pingping Chakravorty, Nishant Wu, Chengtie Xiao, Yin Xu, Mengchi Chang, Jiang
Copyright Year	2014
Abstract	It is accepted that the accelerated differentiation of tissue cells on bioactive materials is of great importance to regenerate the lost tissues. It was previously reported that lithium (Li) ions could enhance the in vitro proliferation and differentiation of retinoblastoma cells and endometrium epithelia by activating the Wnt canonical signalling pathway. It is interesting to incorporate Li ions into bioactive ceramics, such as β-tricalcium phosphate (Li-β-TCP), in order to stimulate both osteogenic and cementogenic differentiation of different stem cells for the regeneration of bone/periodontal tissues. Therefore, the aim of this study was to investigate the interactions of human periodontal ligament cells (hPDLCs) and human bone marrow stromal cells (hBMSCs) with Li-β-TCP bioceramic bulks and their ionic extracts, and further explore the osteogenic and cementogenic stimulation of Li-β-TCP bioceramics and the possible molecular mechanisms. The results showed that Li-β-TCP bioceramic disks supported the cell attachment and proliferation, and significantly enhanced bone/cementum-related gene expression, Wnt canonical signalling pathway activation for both hPDLCs and hBMSCs, compared to conventional β-TCP bioceramic disks without Li. The release of Li from Li-β-TCP powders could significantly promote the bone/cementum-related gene expression for both hPDLCs and hBMSCs compared to pure β-TCP extracts without Li release. Our results suggest that the combination of Li with β-TCP bioceramics may be a promising method to enhance bone/cementum regeneration as Li-β-TCP possesses excellent in vitro osteogenic and cementogenic stimulation properties by inducing bone/cementum-related gene expression in both hPDLCs and hBMSCs.
Starting Page	1230
Ending Page	1243
Page Count	14
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	2
Issue Number	9
Journal	Biomaterials Science
DOI	10.1039/c4bm00111g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Periodontal fiber Phosphorylation Wnt signaling pathway Gene Bioceramic Retinoblastoma protein Bone marrow Lithium Bone Li Endometrium Cementum
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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Lithium release from β-tricalcium phosphate inducing cementogenic and osteogenic differentiation of both hPDLCs and hBMSCs