NDLI: Mesoporous nanogold–MnO<sub>2</sub>–poly(<i>o</i>-phenylenediamine) hollow microspheres as nanotags and peroxidase mimics for sensing biomolecules

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Alteration of epigenetic program to recover memory and alleviate neurodegeneration: prospects of multi-target molecules

A nanocomposite approach to develop biodegradable thermogels exhibiting excellent cell-compatibility for injectable cell delivery

Gelatin hydrogels formed by orthogonal thiol–norbornene photochemistry for cell encapsulation

Mesoporous nanogold–MnO₂–poly(o-phenylenediamine) hollow microspheres as nanotags and peroxidase mimics for sensing biomolecules

Silver nanoparticle loaded PLGA composite nanoparticles for improving therapeutic efficacy of recombinant IFNγ by targeting the cell surface

Adhesion of lactoferrin and bone morphogenetic protein-2 to a rutile surface: dependence on the surface hydrophobicity

Comparative studies of thermogels in preventing post-operative adhesions and corresponding mechanisms

Incorporating the BMP-2 peptide in genetically-engineered biomaterials accelerates osteogenic differentiation

A fluorescently labelled sialic acid for high performance intraoperative tumor detection

Shape directed biomineralization of gold nanoparticles using self-assembled lipid structures

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Mesoporous nanogold–MnO₂–poly(o-phenylenediamine) hollow microspheres as nanotags and peroxidase mimics for sensing biomolecules

Content Provider	Royal Society of Chemistry (RSC)
Author	Lai, Wenqiang Tang, Dianping Que, Xiaohua Fu, Libing Zhuang, Junyang
Copyright Year	2014
Abstract	A new electrochemical immunosensor was designed for the determination of carcinoembryonic antigen (CEA) with sensitivity enhanced by using nanogold–poly(o-phenylenediamine)–manganese dioxide organic–inorganic hybrid nanostructures (GNPM) as nanotags and peroxidase mimics. Initially, mesoporous poly(o-phenylenediamine)–manganese dioxide (PPD–MnO2) hollow microspheres were synthesized by an inorganic/organic interfacial polymerization technique. Then gold nanoparticles were assembled onto the surface of PPD–MnO2, which were used for the labelling of the anti-CEA detection antibody (pAb2). The prepared GNPM nanotags were characterized using transmission electron microscopy (TEM), field emission scanning electron microscopy (FESEM), UV-vis absorption spectroscopy, N2 adsorption–desorption isotherm measurements and Fourier transform infrared spectroscopy (FTIR). The assay was carried out with a sandwich-type immunoassay format in pH 5.5 acetic acid-buffered saline solution containing 2.5 mmol L−1 H2O2. Experimental results indicated that the electrochemical immunosensor exhibited a wide dynamic range from 0.01 to 80 ng mL−1 towards the target CEA with a detection limit (LOD) of 6.0 pg mL−1. The immunosensor also displayed a good stability and acceptable reproducibility and selectivity. In addition, the methodology was evaluated by assaying 10 clinical serum samples, providing a good relationship between the electrochemical immunosensor and the commercialized electrochemiluminescent (ECL) method for determination of CEA.
Starting Page	1073
Ending Page	1079
Page Count	7
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	2
Issue Number	8
Journal	Biomaterials Science
DOI	10.1039/c3bm60284b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Spectroscopy Immunoassay Hydrogen peroxide PPD Polymerization Fourier-transform infrared spectroscopy Scanning electron microscope ECL Manganese dioxide Carcinoembryonic antigen Mesoporous material O-Phenylenediamine Transmission electron microscopy Fourier Wide dynamic range Electrochemistry PH Peroxidase CEA
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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Mesoporous nanogold–MnO2–poly(o-phenylenediamine) hollow microspheres as nanotags and peroxidase mimics for sensing biomolecules

Iron tetrasulfophthalocyanine as catalyst of o-phenylenediamine (OPD) oxidation with molecular oxygen

Graphene-Prussian blue/gold nanoparticles based electrochemical immunoassay of carcinoembryonic antigen

Manganese hexacyanoferrate/MnO₂ composite nanostructures as a cathode material for supercapacitors

Ternary Pt@Pd@Ru nanodendrite-decorated graphene oxide for sensitive electrochemical immunoassy of CEA

Development of MnO₂/porous carbon microspheres with a partially graphitic structure for high performance supercapacitor electrodes

Studies Of MnO2 As Active Material For Electrochemical Supercapacitors

Self-assembly preparation of mesoporous hollow nanospheric manganese dioxide and its application in zinc-air battery

Poly(o-phenylenediamine) nanosphere-conjugated capture antibody immobilized on a glassy carbon electrode for electrochemical immunoassay of carcinoembryonic antigen

Mesoporous nanogold–MnO₂–poly(o-phenylenediamine) hollow microspheres as nanotags and peroxidase mimics for sensing biomolecules

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Mesoporous nanogold–MnO₂–poly(o-phenylenediamine) hollow microspheres as nanotags and peroxidase mimics for sensing biomolecules