NDLI: Biomimetic ECM coatings for controlled release of rhBMP-2: construction and biological evaluation

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A peptide functionalized poly(ethylene glycol) (PEG) hydrogel for investigating the influence of biochemical and biophysical matrix properties on tumor cell migration

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Biomimetic ECM coatings for controlled release of rhBMP-2: construction and biological evaluation

Content Provider	Royal Society of Chemistry (RSC)
Author	Zhao, Shifang Luo, Qiaojie Zha, Guangyu Zhang, Jianxiang Li, Xiaohui Li, Xiaodong Huang, Ying
Copyright Year	2014
Abstract	As we all know biochemical surface modification is promising for implantable biomedical device applications due to its ability to directly provide therapeutic molecular cues for tissue repair. However, presenting multiple molecular cues on implant surfaces in the proper way is challenging. In this study, a multi-component polyelectrolyte multilayer (PEM) coating composed of collagen type I, RGD peptide functionalized hyaluronic acid, and recombined human BMP-2 (rhBMP-2) was constructed on Ti via a layer by layer technique. Subsequently, this coating was crosslinked via disulfide bonds to form a surface gel coating with a semi-interpenetrating network. A disulfide-crosslinked RGD-containing biomimetic extracellular matrix coating that could serve as a reservoir for rhBMP-2 was thus obtained. The embedded rhBMP-2 displayed a sustained release profile and a strong resistance to the physiological environment. In vitro biological evaluation revealed that the resultant disulfide crosslinking bioactive coating could effectively modulate cellular behaviors of pre-osteoblasts such as adhesion, proliferation and differentiation. In vivo study further revealed that this coating could enhance the bone-to-implant integration characterized by the increased removal torque values.
Starting Page	980
Ending Page	989
Page Count	10
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	2
Issue Number	7
Journal	Biomaterials Science
DOI	10.1039/c3bm60254k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Polyelectrolyte Acid Torque Bone morphogenetic protein 2 Biomimetics Disulfide Pressure vessel Extracellular matrix Type I collagen Peptide
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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