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Back cover

Biomaterials Science Vol - 2 Issue - 3

Biomaterials Science Vol - 2 Issue - 2

Biomaterials Science Vol -1

Covalent attachment of multilayers (CAM): a platform for pH switchable antimicrobial and anticoagulant polymeric surfaces

Content Provider	Royal Society of Chemistry (RSC)
Author	Urban, Marek W. Andrie, Joseph M. Pearson, Heather A.
Copyright Year	2014
Abstract	These studies show covalent attachment of multilayers (CAM) to chemically alter surfaces to achieve pH switchable antimicrobial and anticoagulant properties. Polyethylene (PE), poly(tetrafluoroethylene) (PTFE), and silicon (Si) surfaces were functionalized by tethering pH-responsive “switching” polyelectrolytes consisting of poly(2-vinyl pyridine) (P2VP) and poly(acrylic acid) (PAA) terminated with NH2 and COOH groups, respectively. At pH < 2.3, the P2VP segments are protonated and expended, but at pH > 5.5, they collapse while the PAA segments are expanded. The presence of terminal NH2 or COOH moieties on P2VP and PAA, respectively, facilitated the opportunity for covalently bonding ampicillin (AMP) and heparin (HEP) to both polyelectrolyte chains. Such surfaces, when exposed to S. aureus, inhibit the growth of microbial films (AMP) as well as anticoagulant properties (HEP). Comparison of “dynamic” pH dependent surfaces developed in these studies with “static” surfaces terminated with (AMP) entities shows significant enhancement in the longevity of surface activity against microbial film formation.
Starting Page	512
Ending Page	521
Page Count	10
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	2
Issue Number	4
Journal	Biomaterials Science
DOI	10.1039/c3bm60238a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Antimicrobial Polyethylene Polytetrafluoroethylene Adenosine monophosphate Anticoagulant Polyelectrolyte PAA Pyridine Aureus Carboxylic acid Ampicillin Covalent bond PH Heparin Tetrafluoroethylene
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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