NDLI: A plasma untargeted metabolomic study of Chinese medicine Zhi-Zi-Da-Huang decoction intervention to alcohol-induced hepatic steatosis

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A plasma untargeted metabolomic study of Chinese medicine Zhi-Zi-Da-Huang decoction intervention to alcohol-induced hepatic steatosis

Content Provider	Royal Society of Chemistry (RSC)
Author	Feng, Fang Meng, Jin Wu, Huan Wang, Dan Wang, Juanjuan
Copyright Year	2017
Abstract	Zhi-Zi-Da-Huang decoction (ZZDHD) is a classical traditional Chinese medicine (TCM) prescription that has been widely used to treat alcoholic liver disease over a millennium in China. However, the hepatoprotective mechanism of ZZDHD remains obscure. In this work, an untargeted metabolomic study based LC-TOF/MS and LC-QqQ/MS was conducted to explore plasma metabolic changes of ZZDHD intervention to alcohol-induced hepatic steatosis (AHS). The XCMS Online platform was used for nonlinear alignment of the data in the time domain, metabolite feature annotation and extraction of the peak intensities. Principal component analysis (PCA) and orthogonal projection to latent structures discriminant analysis (OPLS-DA) were used to examine the data in a multivariate setting. The observations in control, AHS and ZZDHD-dosed groups could be clearly distinguished by PCA and the ZZDHD-dosed group displayed a distinct returning trend to the control group. 16 potential biomarkers which contribute to the therapeutic mechanism of ZZDHD on AHS rats were screened by OPLS-DA. These potential biomarkers mainly involved in the metabolism of amino acids, phospholipids, fatty acids, cholesterols and sphingolipid, which could be useful to further investigate the characteristics of AHS and the hepatoprotective effects of ZZDHD. This study also illustrates that the untargeted metabolomic method is a promising method to identify candidate metabolic biomarkers and understand the mechanism of TCM.
Starting Page	586
Ending Page	592
Page Count	7
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	9
Issue Number	4
Journal	Analytical Methods
DOI	10.1039/c6ay02863b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Huang Metabolomics Hepatoprotection Metabolite Traditional Chinese medicine Sphingolipid Decoction The Observations Metabolism PCA Alcoholic liver disease Blood plasma Projection (linear algebra) Fatty liver Classical mechanics China Linear discriminant analysis TCM Principal component analysis
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

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