NDLI: Untargeted lipidomics study of coronary artery disease by FUPLC-Q-TOF-MS

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Analytical Methods Vol - 8 Issue - 5

Analytical Methods Vol -7

Analytical Methods Vol -6

Analytical Methods Vol -5

Analytical Methods Vol -4

Analytical Methods Vol -3

Analytical Methods Vol -2

Analytical Methods Vol -1

Untargeted lipidomics study of coronary artery disease by FUPLC-Q-TOF-MS

Content Provider	Royal Society of Chemistry (RSC)
Author	Zhang, Ai-Hua Liu, Han Liang, Qun Zhang, Tianyu Jiang, Yan
Copyright Year	2016
Abstract	Coronary heart disease (CHD) has emerged as a major public health problem worldwide. However, the complex biological networks of lipid metabolism of CHD patients are largely unknown. Lipidomics is a branch of metabolomics, which encompasses the global study of lipids and their biological functions. Current mass spectrometry methodologies allow the detection and quantification of multiple molecular lipid species with various structural and functional roles. Here, we developed an untargeted lipidomics approach based on fast ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (FUPLC-Q-TOF-MS) to profile the lipid changes in CHD patients, to discover potential biomarkers to clarify lipid metabolism of CHD patients. Untargeted lipidome analysis coupled with multivariate data analysis clearly discriminated the CHD patients and normal persons. A total of four metabolites, PE(16:1(9Z)/0:0), aldosterone, 2-acyl-sn-glycero-3-phosphocholine, and alhpa-tocopheronic acid, were defined as “marker lipids,” which can be used to distinguish the CHD patients and normal subjects. Differentially expressed metabolites implied that glycerophospholipid metabolism, glycerolipid metabolism, and steroid hormone biosynthesis networks were acutely perturbed by CHD. These findings provide further insights into the lipid profile across a wide range of biochemical pathways of CHD.
Starting Page	1229
Ending Page	1234
Page Count	6
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	8
Issue Number	6
Journal	Analytical Methods
DOI	10.1039/c5ay02258d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Hormone Metabolomics Acid Lipidomics Metabolism High-performance liquid chromatography Multivariate analysis Aldosterone Coronary artery disease Time-of-flight mass spectrometry Lipid Phosphocholine Quadrupole mass analyzer Glycerophospholipid Mass spectrometry Public health
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

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GC-TOF-MS: gas chromatography time-of-flight mass spectrometry UHPLC-QTOF-MS: ultrahigh performance liquid chromatography quadrupole-time-of-flight mass spectrometry PC: phosphatidylcholine HILIC: Hydrophilic Interaction Liquid Chromatography ESI: electrospray ionization MeOX: methoxyamine hydroclor

Untargeted lipidomics study of coronary artery disease by FUPLC-Q-TOF-MS

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