NDLI: Urine metabolomics reveals new insights into hyperlipidemia and the therapeutic effect of rhubarb

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Urine metabolomics reveals new insights into hyperlipidemia and the therapeutic effect of rhubarb

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Analytical Methods Vol - 7 Issue - 6

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Analytical Methods Vol - 7 Issue - 4

Analytical Methods Vol - 7 Issue - 3

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Analytical Methods Vol -1

Urine metabolomics reveals new insights into hyperlipidemia and the therapeutic effect of rhubarb

Content Provider	Royal Society of Chemistry (RSC)
Author	Tan, Yi Zhao, Ying-Yong Miao, Hua Bai, Xu Chen, Hua Yuan, Bin Wang, Yun
Copyright Year	2015
Abstract	Rhubarb has been widely used for the treatment of hyperlipidemia and blood stasis. We conducted an ultra performance liquid chromatography-quadrupole time-of-flight high-definition mass spectrometry-based urinary metabolomic study on the diet-induced hyperlipidemic rats to present new insights into hyperlipidemia and the therapeutic effect of rhubarb. Coupled with blood biochemistry results, a significant difference in metabolic profiles among control, diet-induced hyperlipidemic and rhubarb-treated hyperlipidemic groups by partial least squares-discriminate analysis demonstrated that alterations in global urinary metabolites occurred significantly. Twenty-nine metabolites were identified as potential biomarkers by the accurate mass, isotopic pattern and MSE fragments information in both positive and negative ion modes. Significantly higher levels of octadecanamide, 3-methyluridine, oleamide, ascorbalamic acid, 1-methylnicotinamide, phenylacetylglycine, xanthine, aspartic acid, ribothymidine, 4-aminohippuric acid, methylhippuric acid, arginine and hippuric acid as well as significantly lower levels of 3-O-methyldopa, trimethyltridecanoic acid, S-cysteinosuccinic acid, indole-3-carboxylic acid, creatinine, carnitine, phenylalanine, 2-pyrroloylglycine, phytosphingosine, cyclohexanecarboxylic acid, propionylcarnitine, N-acetylneuraminic acid, cytidine, phenylpropionylglycine, palmitic acid and ribonic acid were observed in the diet-induced hyperlipidemic rats compared with the control rats. However, tendencies of these metabolites were obviously reversed in the rhubarb-treated hyperlipidemic rats. Changes of these metabolites were mainly associated with the perturbations of fatty acid metabolism, amino acid metabolism and nucleoside metabolism. The results indicated the amelioration and the therapeutic effect of rhubarb for hyperlipidemia, and further provided new insights into hyperlipidemia and the therapeutic effect of rhubarb.
Starting Page	3113
Ending Page	3123
Page Count	11
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	7
Issue Number	7
Journal	Analytical Methods
DOI	10.1039/c5ay00023h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Creatinine Metabolomics Phenylalanine Hyperlipidemia Indole High-definition video Ion Biochemistry Xanthine 3-O-Methyldopa Metabolism Time-of-flight mass spectrometry Cytidine Carnitine Arginine Carboxylic acid Fatty acid Oleamide Nucleoside Rhubarb MSE 5-Methyluridine
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

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