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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Srinivas, R. Swamy, Challa Veerabhadra Talluri, M. V. N. Kumar Patel, Prinesh N. Kalariya, Pradipbhai D. |
| Copyright Year | 2015 |
| Abstract | A selective, sensitive and fast liquid chromatography coupled with mass spectrometry method (LC-MS) has been developed and validated for the quantification of tinoridine hydrochloride in rat plasma using ketorolac tromethamine as an internal standard. Pre-treatment of the sample obtained from the plasma involved a simple and reliable protein precipitation method using methanol. A successful chromatographic separation was achieved on a Zorbax extended C18 column (50 mm × 2.1 mm, 1.8 μm) using acetonitrile and 0.1% formic acid as the mobile phase in gradient elution mode with a flow rate of 0.5 mL min−1. Detection was performed with positive ion electrospray ionization mass spectrometry using target ions of [M + H]+ at m/z 317 for tinoridine and m/z 256 for ketorolac in selective ion mode. The method was validated in the calibration range of 2–200 ng mL−1. All the validation parameters were well within the limits. This method was further successfully applied in pharmacokinetic studies of the drug in rats. |
| Starting Page | 1965 |
| Ending Page | 1970 |
| Page Count | 6 |
| File Format | HTM / HTML PDF |
| ISSN | 17599660 |
| Volume Number | 7 |
| Issue Number | 5 |
| Journal | Analytical Methods |
| DOI | 10.1039/c4ay02898h |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Acid Protein precipitation Ketorolac Electrospray ionization Ion High-performance liquid chromatography Chromatography Blood plasma Tris Ionization Micrometre Acetonitrile Pharmacokinetics Mass spectrometry Methanol |
| Content Type | Text |
| Resource Type | Article |
| Subject | Analytical Chemistry Engineering Chemical Engineering |
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