NDLI: A sensitive, switchable and biocompatible surface enhanced Raman scattering-fluorescence dual mode probe using bipyramid gold nanocrystal-gold nanoclusters for high-throughput biodetection

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A sensitive, switchable and biocompatible surface enhanced Raman scattering-fluorescence dual mode probe using bipyramid gold nanocrystal-gold nanoclusters for high-throughput biodetection

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Analytical Methods Vol - 6 Issue - 8

Analytical Methods Vol - 6 Issue - 7

Analytical Methods Vol - 6 Issue - 6

Analytical Methods Vol - 6 Issue - 5

Analytical Methods Vol - 6 Issue - 4

Analytical Methods Vol - 6 Issue - 3

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Analytical Methods Vol -1

A sensitive, switchable and biocompatible surface enhanced Raman scattering-fluorescence dual mode probe using bipyramid gold nanocrystal-gold nanoclusters for high-throughput biodetection

Content Provider	Royal Society of Chemistry (RSC)
Author	Xiaofei, Wu Zaijun, Li Xiaoyan, Zhou Ruiyi, Li
Copyright Year	2014
Abstract	High-throughput biodetection based on optical codes increasingly received significant attention regarding food safety, molecular biology analysis and disease diagnosis. However, the present probe lacks the desired biocompatibility, specificity, sensitivity and code capacity. Here, we reported the synthesis of bipyramid gold nanocrystal-gold nanoclusters (BPGN/GNC) and their application as new dual mode probe for high-throughput biodetection. The hybrid nanoparticles offer excellent biocompatibility owing to the adoption of non-toxic gold nanocrystals, and a strong surface enhanced Raman scattering (SERS) signal of the SERS reporter because of the unique optical and electronic properties of BPGN, which is more than 17-fold that of the probe using gold nanoparticles and 6-fold that of the probe using gold nanorods. The fluorescence and SERS signals of the probe can be separately generated when excited at wavelengths as 365 and 785 nm, which avoids disturbance from each other. The SERS-fluorescence joint spectral encoding method provides a broadened optical spectrum range for efficient encoding as compared to a single SERS or fluorescence-based encoding protocol. Such new concept of an optical encoding approach was successfully applied to simultaneously detect aflatoxin B1, B2, G1, G2, M1 and M2 with ultrahigh sensitivity and specificity. The study also opens a new way in an optical encoding system, which could have enormous potential applications in high-throughout bioanalysis.
Starting Page	2862
Ending Page	2869
Page Count	8
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	6
Issue Number	9
Journal	Analytical Methods
DOI	10.1039/c3ay41966e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Surface-enhanced Raman spectroscopy Fluorescence M1 motorway Spectrum Range Reporter gene SERS General National Congress Bioanalysis Biosensor Biocompatibility Raman Food safety Molecular biology Nanorod Aflatoxin
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

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A sensitive, switchable and biocompatible surface enhanced Raman scattering-fluorescence dual mode probe using bipyramid gold nanocrystal-gold nanoclusters for high-throughput biodetection

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Site-selective localization of analytes on gold nanorod surface for investigating field enhancement distribution in surface-enhanced Raman scattering

Gold Nanoparticles With Special Shapes: Controlled Synthesis, Surface-enhanced Raman Scattering, and The Application in Biodetection

Characterization of Labeled Gold Nanoparticles for Surface-Enhanced Raman Scattering

Excitation Conditions for Surface-Enhanced Hyper Raman Scattering With Biocompatible Gold Nanosubstrates

Nanoparticles with special shapes: controlled synthesis, surface-enhanced raman scattering, and the application in biodetection. Sensors 2007; 7.

A sensitive, switchable and biocompatible surface enhanced Raman scattering-fluorescence dual mode probe using bipyramid gold nanocrystal-gold nanoclusters for high-throughput biodetection

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