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| Content Provider | PubMed Central |
|---|---|
| Author | Mattsson, Eva Herwald, Heiko Cramer, Henning Persson, Kristin Sjöbring, Ulf Björck, Lars |
| Editor | Kozel, T. R. |
| Copyright Year | 2001 |
| Abstract | Staphylococcus aureus is a prominent human pathogen. Here we report that intact S. aureus bacteria activate the contact system in human plasma in vitro, resulting in a massive release of the potent proinflammatory and vasoactive peptide bradykinin. In contrast, no such effect was recorded with Streptococcus pneumoniae. In the activation of the contact system, blood coagulation factor XII and plasma kallikrein play central roles, and a specific inhibitor of these serine proteinases inhibited the release of bradykinin by S. aureus in human plasma. Furthermore, fragments of the cofactor H-kininogen of the contact system efficiently blocked bradykinin release. The results suggest that activation of the contact system at the surface of S. aureus and the subsequent release of bradykinin could contribute to the hypovolemic hypotension seen in patients with severe S. aureus sepsis. The data also suggest that the contact system could be used as a target in the treatment of S. aureus infections. |
| Related Links | http://dx.doi.org/10.1128/iai.69.6.3877-3882.2001 |
| Ending Page | 3882 |
| Page Count | 6 |
| Starting Page | 3877 |
| File Format | |
| ISSN | 00199567 |
| e-ISSN | 10985522 |
| Journal | Infection and Immunity |
| Issue Number | 6 |
| Volume Number | 69 |
| Language | English |
| Publisher | American Society for Microbiology |
| Publisher Date | 2001-06-01 |
| Access Restriction | Open |
| Rights Holder | American Society for Microbiology |
| Subject Keyword | Immunology Microbiology Parasitology Infectious Diseases Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Parasitology Immunology Microbiology |
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