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| Content Provider | PubMed Central |
|---|---|
| Author | Landry, Marie L. Sylvia, Stanat Biron, Karen Brambilla, Donald Britt, William Jokela, Janet Chou, Sunwen Drew, W. Lawrence Erice, Alejo Gilliam, Bruce Nell, Lurain Manischewitz, Jody Miner, Richard Mostafa, Nokta Reichelderfer, Patricia Spector, Stephen Weinberg, Adriana Belinda, Yen-lieberman Crumpacker, Clyde |
| Copyright Year | 2000 |
| Abstract | Twelve laboratories collaborated in formulating and testing a standardized plaque reduction assay for cytomegalovirus (CMV) cell-associated clinical isolates. Four characterized and plaque-purified CMV strains, as well as six coded clinical isolates obtained after antiviral therapy, were distributed and tested. Good agreement was obtained for four of the clinical isolates, but a broad distribution of results was obtained for two isolates. Analysis of these results indicates the problems associated with clinical isolates, including the large genetic variability and the highly cell-associated phenotype. This collaborative effort, by addressing these problems, represents a significant step toward the development of a standardized assay. |
| Starting Page | 688 |
| File Format | |
| ISSN | 10986596 |
| e-ISSN | 10986596 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Issue Number | 3 |
| Volume Number | 44 |
| Language | English |
| Publisher | American Society for Microbiology |
| Publisher Date | 2000-03-01 |
| Access Restriction | Open |
| Rights Holder | American Society for Microbiology |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Pharmacology Pharmacology (medical) |
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