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| Content Provider | PubMed Central |
|---|---|
| Author | Ida, Takashi Okamoto, Ryoichi Shimauchi, Chieko Okubo, Toyoji Kuga, Akio Inoue, Matsuhisa |
| Copyright Year | 2001 |
| Abstract | A multiple-primer PCR was used to identify genes encoding aminoglycoside-modifying enzymes in 381 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). The technique used three sets of primers delineating specific DNA fragments of the aph(3′)-III, ant(4′)-I, and aac(6′)-aph(2") genes, which influence the MICs of gentamicin, tobramycin, and lividomycin. Isolates with none of the three genes detected were susceptible to all three agents. Isolates with the aph(3′)-III gene showed resistance to lividomycin (MIC > 1,024 μg/ml), and those with the ant(4′)-I gene were resistant to tobramycin (MIC ≥ 8 μg/ml). Isolates with only the aac(6′)-aph(2") gene were resistant to gentamicin (MIC ≥ 8 μg/ml) and tobramycin in decreasing order; those with both the ant(4′)-I and aac(6′)-aph(2") genes also were resistant to gentamicin and tobramycin, but in increasing order. Susceptibility testing, then, could detect specific genes. In 381 Japanese MRSA isolates, the ant(4′)-I, aac(6′)-aph(2"), and aph(3′)-III genes were prevalent in 84.5, 61.7, and 8.9%, respectively. Isolates with only the ant(4′)-I gene had coagulase type II or III, but isolates with both the ant(4′)-I and aac(6′)-aph(2") genes included all coagulase types. Most isolates with coagulase type IV or VII carried the aac(6′)-aph(2") gene. Of the MRSA isolates with ant(4′)-I and/or aac(6′)-aph(2") genes, 97% were resistant to aminoglycosides in clinical use, but a new aminoglycoside, arbekacin, had excellent activity against these isolates. |
| Related Links | http://dx.doi.org/10.1128/jcm.39.9.3115-3121.2001 |
| Ending Page | 3121 |
| Page Count | 7 |
| Starting Page | 3115 |
| File Format | |
| ISSN | 00951137 |
| e-ISSN | 1098660X |
| Journal | Journal of Clinical Microbiology |
| Issue Number | 9 |
| Volume Number | 39 |
| Language | English |
| Publisher | American Society for Microbiology |
| Publisher Date | 2001-09-01 |
| Access Restriction | Open |
| Rights Holder | American Society for Microbiology |
| Subject Keyword | Microbiology (medical) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Microbiology (medical) |
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