NDLI: CD26-mediated signaling for T cell activation occurs in lipid rafts through its association with CD45RO

Content Provider	PubMed Central
Author	Ishii, Tomonori Kei, Ohnuma Murakami, Akikazu Takasawa, Naruhiko Kobayashi, Seiji Dang, Nam H. Schlossman, Stuart F. Morimoto, Chikao
Copyright Year	2001
Abstract	CD26 is a T cell activation antigen that contains dipeptidyl peptidase IV activity and is known to bind adenosine deaminase. The mechanism by which CD26 costimulation potentiates T cell receptor-mediated T cell activation, leading to subsequent exertion of T cell effector function, is still not clearly defined. In this article, we demonstrate that CD26 localizes into lipid rafts, and targeting of CD26 to rafts is necessary for signaling events through CD26. Importantly, aggregation of CD26 by anti-CD26 mAb crosslinking also causes coaggregation of CD45 into rafts. Moreover, we show that CD26 directly binds to the cytoplasmic domain of CD45. Our results therefore indicate a mechanism whereby CD26 engagement promotes aggregation of lipid rafts and facilitates colocalization of CD45 to T cell receptor signaling molecules p56Lck, ZAP-70, and TCRζ, thereby enhancing protein tyrosine phosphorylation of various signaling molecules and subsequent interleukin-2 production.
Related Links	http://dx.doi.org/10.1073/pnas.211439098
Ending Page	12143
Page Count	6
Starting Page	12138
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	21
Volume Number	98
Language	English
Publisher	The National Academy of Sciences
Publisher Date	2001-10-09
Access Restriction	Open
Rights Holder	The National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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