NDLI: Heterosynaptic metaplasticity in the hippocampus in vivo: A BCM-like modifiable threshold for LTP

Content Provider	PubMed Central
Author	Abraham, Wickliffe C. Mason-parker, Sara E. Bear, Mark F. Webb, Sarah Tate, Warren P.
Copyright Year	2001
Abstract	The homeostatic maintenance of the “modification threshold” for inducing long-term potentiation (LTP) is a fundamental feature of the Bienenstock, Cooper, and Munro (BCM) model of synaptic plasticity. In the present study, two key features of the modification threshold, its heterosynaptic expression and its regulation by postsynaptic neural activity, were tested experimentally in the dentate gyrus of awake, freely moving rats. Conditioning stimulation ranging from 10 to 1,440 brief 400-Hz trains, when applied to medial perforant path afferents, raised the threshold for LTP induction heterosynaptically in the neighboring lateral perforant path synapses. This effect recovered slowly over a 7- to 35-day period. The same conditioning paradigms, however, did not affect the reversal of long-term depression. The inhibition of LTP by medial-path conditioning stimulation was N-methyl-D-aspartate (NMDA) receptor-dependent, but antidromic stimulation of the granule cells could also inhibit lateral path LTP induction, independently of NMDA receptor activation. Increased calcium buffering is a potential mechanism underlying the altered LTP threshold, but the levels of two important calcium-binding proteins did not increase after conditioning stimulation, nor was de novo protein synthesis required for generating the threshold shift. These data confirm, in an in vivo model, two key postulates of the BCM model regarding the LTP threshold. They also provide further evidence for the broad sensitivity of synaptic plasticity mechanisms to the history of prior activity, i.e., metaplasticity.
Related Links	http://dx.doi.org/10.1073/pnas.181342098
Ending Page	10929
Page Count	6
Starting Page	10924
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	19
Volume Number	98
Language	English
Publisher	The National Academy of Sciences
Publisher Date	2001-09-11
Access Restriction	Open
Rights Holder	The National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Heterosynaptic metaplasticity in the hippocampus in vivo: a BCM-like modifiable threshold for LTP.

Correction: A Voltage-Based STDP Rule Combined with Fast BCM-Like Metaplasticity Accounts for LTP and Concurrent "Heterosynaptic" LTD in the Dentate Gyrus In Vivo.

STDP rule endowed with the BCM sliding threshold accounts for hippocampal heterosynaptic plasticity

Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus.

Correction: A Voltage-Based STDP Rule Combined with Fast BCM-Like Metaplasticity Accounts for LTP and Concurrent "Heterosynaptic" LTD in the Dentate Gyrus In Vivo

A Voltage-Based STDP Rule Combined with Fast BCM-Like Metaplasticity Accounts for LTP and Concurrent “Heterosynaptic” LTD in the Dentate Gyrus In Vivo

A requirement for epigenetic modifications during noradrenergic stabilization of heterosynaptic LTP in the hippocampus

Stdp rule endowed with the bcm sliding threshold accounts for hippocampal heterosynaptic plasticity (2007).

Bidirectional NMDA receptor plasticity controls CA3 output and heterosynaptic metaplasticity.

Heterosynaptic metaplasticity in the hippocampus in vivo: A BCM-like modifiable threshold for LTP

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Heterosynaptic metaplasticity in the hippocampus in vivo: a BCM-like modifiable threshold for LTP.

Correction: A Voltage-Based STDP Rule Combined with Fast BCM-Like Metaplasticity Accounts for LTP and Concurrent "Heterosynaptic" LTD in the Dentate Gyrus In Vivo.

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