NDLI: Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid.

Please wait, while we are loading the content...

Year: 2016, Volume: 35

Year: 2015, Volume: 34

Year: 2014, Volume: 33

Year: 2013, Volume: 33

Year: 2013, Volume: 32

Year: 2012, Volume: 32

Year: 2012, Volume: 31

Year: 2011, Volume: 30

Year: 2010, Volume: 29

Year: 2009, Volume: 28

Year: 2008, Volume: 27

Year: 2007, Volume: 26

Year: 2006, Volume: 26

Year: 2006, Volume: 25

Year: 2005, Volume: 24

Year: 2004, Volume: 24

Year: 2004, Volume: 23

Year: 2003, Volume: 22

Year: 2002, Volume: 21

Year: 2001, Volume: 20

Year: 2000, Volume: 19

Year: 1999, Volume: 18

Year: 1998, Volume: 17

Year: 1997, Volume: 16

Year: 1996, Volume: 15

Year: 1995, Volume: 14

Year: 1994, Volume: 13

Year: 1993, Volume: 12

Year: 1992, Volume: 11

Year: 1992, Volume: 11, Issue: 13

Year: 1992, Volume: 11, Issue: 12

Year: 1992, Volume: 11, Issue: 11

Year: 1992, Volume: 11, Issue: 10

Year: 1992, Volume: 11, Issue: 9

Year: 1992, Volume: 11, Issue: 8

Year: 1992, Volume: 11, Issue: 7

Higher rate of evolution of X chromosome alpha-repeat DNA in human than in the great apes.

Three-dimensional structure of transketolase, a thiamine diphosphate dependent enzyme, at 2.5 A resolution.

Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase.

Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator.

Evidence for the presence of a secondary structure at the dibasic processing site of prohormone: the pro-ocytocin model.

Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease.

Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: lack of evidence for labile repressors.

Targeted degradation of the retinoblastoma protein by human papillomavirus E7-E6 fusion proteins.

The 'second-codon rule' and autophosphorylation govern the stability and activity of Mos during the meiotic cell cycle in Xenopus oocytes.

Differential occurrence of CSF-like activity and transforming activity of Mos during the cell cycle in fibroblasts.

The aerolysin membrane channel is formed by heptamerization of the monomer.

Different types of K+ channel current are generated by different levels of a single mRNA.

Characterization of a Shaw-related potassium channel family in rat brain.

Regulation of CFTR expression and function during differentiation of intestinal epithelial cells.

Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid.

Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding.

OCH1 encodes a novel membrane bound mannosyltransferase: outer chain elongation of asparagine-linked oligosaccharides.

Amphiphysin, a novel protein associated with synaptic vesicles.

Giant lens, a gene involved in cell determination and axon guidance in the visual system of Drosophila melanogaster.

Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex.

Brain 4: a novel mammalian POU domain transcription factor exhibiting restricted brain-specific expression.

Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development.

Transcription factor AP-2 activates gene expression of HTLV-I.

A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins.

Suppression of beta-1,3-glucanase transgene expression in homozygous plants.

Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor.

Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain.

DNA deformation in nucleoprotein complexes between RNA polymerase, cAMP receptor protein and the lac UV5 promoter probed by singlet oxygen.

The positive regulator CfaD overcomes the repression mediated by histone-like protein H-NS (H1) in the CFA/I fimbrial operon of Escherichia coli.

E.coli polynucleotide phosphorylase expression is autoregulated through an RNase III-dependent mechanism.

Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A.

Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.

Co-amplified markers alternate in megabase long chromosomal inverted repeats and cluster independently in interphase nuclei at early steps of mammalian gene amplification.

Replication control of plasmid R1: RepA synthesis is regulated by CopA RNA through inhibition of leader peptide translation.

Unusual stability of recombination intermediates made by Escherichia coli RecA protein.

Sequence-specific interaction of the Salmonella Hin recombinase in both major and minor grooves of DNA.

An endonuclease with multiple cutting sites, Endo.SceI, initiates genetic recombination at its cutting site in yeast mitochondria.

Yeast mitochondrial DNA mutators with deficient proofreading exonucleolytic activity.

Surface IgM mediated regulation of RAG gene expression in E mu-N-myc B cell lines.

T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines.

Role of associated gamma-chain in tyrosine kinase activation via murine Fc gamma RIII.

A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible.

Year: 1992, Volume: 11, Issue: 6

Year: 1992, Volume: 11, Issue: 5

Year: 1992, Volume: 11, Issue: 4

Year: 1992, Volume: 11, Issue: 3

Year: 1992, Volume: 11, Issue: 2

Year: 1992, Volume: 11, Issue: 1

Year: 1991, Volume: 10

Year: 1990, Volume: 9

Year: 1989, Volume: 8

Year: 1988, Volume: 7

Year: 1987, Volume: 6

Year: 1986, Volume: 5

Year: 1985, Volume: 4

Year: 1984, Volume: 3

Year: 1983, Volume: 2

Year: 1982, Volume: 1

Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid.

Content Provider	PubMed Central
Author	Bend, R. L. Van Der Brunner, J. Jalink, K. Van, Corven E. J. Moolenaar, W. H. Blitterswijk, W. J. Van
Abstract	Lysophosphatidic acid (LPA) is a naturally occurring phospholipid with hormone- and growth factor-like activities. Exogenous LPA stimulates GTP-dependent phosphoinositide hydrolysis and inhibits adenylate cyclase in its target cells, but the site of action of LPA is unknown. We now report the identification by photoaffinity labeling of a putative LPA membrane receptor in various LPA-responsive cell types. A 32P-labeled LPA analogue containing a photoreactive fatty acid, [32P]diazirine-LPA, labels a membrane protein of apparent molecular mass of 38-40 kDa in various cell types, including neuronal cells, brain homogenates, carcinoma cells, leukemic cells and normal fibroblasts. Labeling of the 38-40 kDa protein is competitively inhibited by unlabeled 1-oleoyl-LPA (IC50 approximately 10 nM), but not by other phospholipids. Specific labeling is not detected in rat liver membranes or in human neutrophils, which are physiologically unresponsive to LPA. Suramin, an inhibitor of both early and late events in the action of LPA, completely inhibits the binding of photoreactive LPA. We suggest that the 38-40 kDa protein represents a specific LPA cell surface receptor mediating at least part of the multiple cellular responses to LPA.
Starting Page	2495
File Format	PDF
ISSN	14602075
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	7
Volume Number	11
Language	English
Publisher Date	1992-07-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in