NDLI: A synthetic homeodomain binding site acts as a cell type specific, promoter specific enhancer in Drosophila embryos.

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A synthetic homeodomain binding site acts as a cell type specific, promoter specific enhancer in Drosophila embryos.

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A synthetic homeodomain binding site acts as a cell type specific, promoter specific enhancer in Drosophila embryos.

Content Provider	PubMed Central
Author	Vincent, J. P. Kassis, J. A. O'farrell, P. H.
Abstract	A DNA sequence initially defined as a consensus binding site for the Engrailed protein is also recognized by several other homeodomain proteins and mediates the transcriptional action of these regulators in transfected tissue culture cells. Here we show that these synthetic binding sites have a more restricted and specific ability to enhance transcription when assayed in transformed embryos. Several constructs with the homeodomain binding sites linked to the fushi tarazu or engrailed promoters are silent in transformed embryos. However, when linked to the hsp70 promoter, the sites specifically activate transcription in glial cells. The effect of single base pair mutations in the binding sites suggests that activation is mediated by homeodomain protein(s). We suggest that this specific pattern of expression results from combined action at sequences within the hsp70 promoter fragment and the homeodomain binding sites. Since the tissue culture transfection assay does not show such rigid constraints on promoter activation by homeodomain proteins, it appears that subsidiary phenomena apparent in the transgenic embryos contribute importantly to the specificity of action of functionally homologous homeodomain regulators.
Starting Page	2573
File Format	PDF
ISSN	14602075
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	8
Volume Number	9
Language	English
Publisher Date	1990-08-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

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