NDLI: ADAM10 cleavage of N-cadherin and regulation of cell–cell adhesion and β-catenin nuclear signalling

Content Provider	PubMed Central
Author	Reiss, Karina Thorsten, Maretzky Ludwig, Andreas Thomas, Tousseyn Strooper, Bart De Hartmann, Dieter Saftig, Paul
Copyright Year	2005
Abstract	Cadherins are critically involved in tissue development and tissue homeostasis. We demonstrate here that neuronal cadherin (N-cadherin) is cleaved specifically by the disintegrin and metalloproteinase ADAM10 in its ectodomain. ADAM10 is not only responsible for the constitutive, but also for the regulated, shedding of this adhesion molecule in fibroblasts and neuronal cells directly regulating the overall levels of N-cadherin expression at the cell surface. The ADAM10-induced N-cadherin cleavage resulted in changes in the adhesive behaviour of cells and also in a dramatic redistribution of β-catenin from the cell surface to the cytoplasmic pool, thereby influencing the expression of β-catenin target genes. Our data therefore demonstrate a crucial role of ADAM10 in the regulation of cell–cell adhesion and on β-catenin signalling, leading to the conclusion that this protease constitutes a central switch in the signalling pathway from N-cadherin at the cell surface to β-catenin/LEF-1-regulated gene expression in the nucleus.
Related Links	http://dx.doi.org/10.1038/sj.emboj.7600548
Ending Page	752
Page Count	11
Starting Page	742
File Format	PDF
ISSN	02614189
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	4
Volume Number	24
Language	English
Publisher Date	2005-02-01
Access Restriction	Open
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Neuroscience(all) Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

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