NDLI: Evolutionarily conserved human targets of adenosine to inosine RNA editing

Content Provider	PubMed Central
Author	Levanon, Erez Y. Martina, Hallegger Yaron, Kinar Shemesh, Ronen Kristina, Djinovic-carugo Gideon, Rechavi Jantsch, Michael F. Eisenberg, Eli
Copyright Year	2005
Abstract	A-to-I RNA editing by ADARs is a post-transcriptional mechanism for expanding the proteomic repertoire. Genetic recoding by editing was so far observed for only a few mammalian RNAs that are predominantly expressed in nervous tissues. However, as these editing targets fail to explain the broad and severe phenotypes of ADAR1 knockout mice, additional targets for editing by ADARs were always expected. Using comparative genomics and expressed sequence analysis, we identified and experimentally verified four additional candidate human substrates for ADAR-mediated editing: FLNA, BLCAP, CYFIP2 and IGFBP7. Additionally, editing of three of these substrates was verified in the mouse while two of them were validated in chicken. Interestingly, none of these substrates encodes a receptor protein but two of them are strongly expressed in the CNS and seem important for proper nervous system function. The editing pattern observed suggests that some of the affected proteins might have altered physiological properties leaving the possibility that they can be related to the phenotypes of ADAR1 knockout mice.
Related Links	http://dx.doi.org/10.1093/nar/gki239
Ending Page	1168
Page Count	7
Starting Page	1162
File Format	PDF
ISSN	13624962
e-ISSN	13624962
Journal	Nucleic Acids Research
Issue Number	4
Volume Number	33
Language	English
Publisher	Oxford University Press
Publisher Date	2005-02-23
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Genetics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics

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