NDLI: A push-pull mechanism for regulating integrin function

Content Provider	PubMed Central
Author	Li, Wei Metcalf, Douglas G. Gorelik, Roman Li, Renhao Mitra, Neal Nanda, Vikas Law, Peter B. Lear, James D. Degrado, William F. Bennett, Joel S.
Copyright Year	2005
Abstract	Homomeric and heteromeric interactions between the αIIb and β3 transmembrane domains are involved in the regulation of integrin αIIbβ3 function. These domains appear to interact in the inactivated state but separate upon integrin activation. Moreover, homomeric interactions may increase the level of αIIbβ3 activity by competing for the heteromeric interaction that specifies the resting state. To test this model, a series of mutants were examined that had been shown previously to either enhance or disrupt the homomeric association of the αIIb transmembrane domain. One mutation that enhanced the dimerization of the αIIb transmembrane domain indeed induced constitutive αIIbβ3 activation. However, a series of mutations that disrupted homodimerization also led to αIIbβ3 activation. These results suggest that the homo- and heterodimerization motifs overlap in the αIIb transmembrane domain, and that mutations that disrupt the αIIb/β3 transmembrane domain heterodimer are sufficient to activate the integrin. The data also imply a mechanism for αIIbβ3 regulation in which the integrin can be shifted from its inactive to its active state by destabilizing an αIIb/β3 transmembrane domain heterodimer and by stabilizing the resulting αIIb and β3 transmembrane domain homodimers.
Related Links	http://dx.doi.org/10.1073/pnas.0409334102
Starting Page	1424
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	102
Language	English
Publisher	National Academy of Sciences
Publisher Date	2005-02-01
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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