NDLI: dsu functions in a MYO5A-independent pathway to suppress the coat color of dilute mice

Content Provider	PubMed Central
Author	O'sullivan, T. Norene Wu, Xufeng S. Rachel, Rivka A. Huang, Jiang-dong Swing, Deborah A. Matesic, Lydia E. Hammer, John A. Copeland, Neal G. Jenkins, Nancy A.
Copyright Year	2004
Abstract	MYO5A is a major actin-based vesicle transport motor that binds to one of its cargos, the melanosome, by means of a RAB27A/MLPH receptor. When one of the members of this receptor–motor complex is mutated, the melanosomes clump in the perinuclear region of the melanocyte and are transferred unevenly to the developing hair, leading to a dilution of coat color. Mutation of a fourth gene, dilute suppressor (dsu), suppresses this coat color dilution. MYO5A is required for the peripheral accumulation of melanosomes in melanocytes, but its role in melanosome transfer to neighboring keratinocytes and the hair is unknown. Here, we show that MYO5A is nonessential for melanosome transfer, although pigment incorporation into the hair in MYO5A-deficient mice is uneven, probably due to the clumping of melanosomes that occurs in the perinuclear region of mutant melanocytes. We also show that dsu is caused by a loss-of-function mutation in a unique vertebrate-specific protein that appears to function in an MYO5A-independent pathway to alter pigment incorporation into the hair. Therefore, dsu identifies a unique protein involved in pigmentation of the mammalian hair.
Related Links	http://dx.doi.org/10.1073/pnas.0407339101
Ending Page	16836
Page Count	6
Starting Page	16831
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	48
Volume Number	101
Language	English
Publisher	National Academy of Sciences
Publisher Date	2004-11-30
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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dsu functions in a MYO5A-independent pathway to suppress the coat color of dilute mice

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