NDLI: Zinc regulates the function of two superantigens.

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Monitoring electron spin by running geonium atom as microaccelerator.

Negative regulation of Rb expression by the p53 gene product.

Direct effect of basic fibroblast growth factor on gene transcription in a cell-free system.

The phorbol ester-dependent activator of the mitogen-activated protein kinase p42mapk is a kinase with specificity for the threonine and tyrosine regulatory sites.

RecBCD enzyme is altered upon cutting DNA at a chi recombination hotspot.

Spontaneous incorporation of the glycosyl-phosphatidylinositol-linked protein Thy-1 into cell membranes.

Role of protein kinase C and transcription factor AP-1 in the acid-induced increase in Na/H antiporter activity.

Restriction mapping of the genome of the protozoan parasite Theileria parva.

Human cytomegalovirus origin of DNA replication (oriLyt) resides within a highly complex repetitive region.

Reversible alterations in myocardial gene expression in a young man with dilated cardiomyopathy and hypothyroidism.

Ribosomal gene clusters are uniquely proportioned between open and closed chromatin structures in both tomato leaf cells and exponentially growing suspension cultures.

BEN, a surface glycoprotein of the immunoglobulin superfamily, is expressed in a variety of developing systems.

Rapid evolution of the human gene for cytochrome c oxidase subunit IV.

Neuronal development in the Drosophila retina: the sextra gene defines an inhibitory component in the developmental pathway of R7 photoreceptor cells.

Enumeration of lymphokine mRNA-containing cells in vivo in a murine graft-versus-host reaction using the PCR.

A molecular mechanism for pyrimidine and purine nucleotide control of aspartate transcarbamoylase.

Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.

Identification of a coactivator that increases activation of transcription by serum response factor and GAL4-VP16 in vitro.

Meiotic recombination and segregation of human-derived artificial chromosomes in Saccharomyces cerevisiae.

Interlocus V-J recombination measures genomic instability in agriculture workers at risk for lymphoid malignancies.

A cobalt-porphyrin enzyme converts a fatty aldehyde to a hydrocarbon and CO.

On the relationship between bird and woody plant species diversity in the Uttara Kannada district of south India.

Genetic organization of a repeated DNA sequence family in the rice blast fungus.

ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization.

Parathyroid hormone-related protein in the rat urinary bladder: a smooth muscle relaxant produced locally in response to mechanical stretch.

Genotypic analysis of N-ethyl-N-nitrosourea-induced mutations by Taq I restriction fragment length polymorphism/polymerase chain reaction in the c-H-ras1 gene.

Selection of intraepithelial lymphocytes with CD8 alpha/alpha co-receptors by self-antigen in the murine gut.

Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain.

A 71-kilodalton protein is a major product of the Duchenne muscular dystrophy gene in brain and other nonmuscle tissues.

Extracellular (axenic) development in vitro of the erythrocytic cycle of Plasmodium falciparum.

Purification of a distinctive form of endotoxin-induced nitric oxide synthase from rat liver.

Gene conversion in Neisseria gonorrhoeae: evidence for its role in pilus antigenic variation.

Expression of monocyte chemoattractant protein 1 mRNA in human idiopathic pulmonary fibrosis.

Structural organization of the gene for prostaglandin D synthase in the rat brain.

Encoded combinatorial chemistry.

Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau.

Adenylosuccinate lyase of Bacillus subtilis regulates the activity of the glutamyl-tRNA synthetase.

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Overlap of the p53-responsive element and cAMP-responsive element in the enhancer of human T-cell leukemia virus type I.

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1.

Preferential repair and strand-specific repair of benzo[a]pyrene diol epoxide adducts in the HPRT gene of diploid human fibroblasts.

Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice.

Cytokinetic failure and asynchronous nuclear division in BHK cells overexpressing a truncated protein-tyrosine-phosphatase.

Fusions near telomeres occur very early in the amplification of CAD genes in Syrian hamster cells.

Mls-1 is encoded by the long terminal repeat open reading frame of the mouse mammary tumor provirus Mtv-7.

Brief visual experience induces immediate early gene expression in the cat visual cortex.

Identification of an interleukin 2-like substance as a factor cytotoxic to oligodendrocytes and associated with central nervous system regeneration.

Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase.

Interaction of Escherichia coli RuvA and RuvB proteins with synthetic Holliday junctions.

A putative gene family in 15q11-13 and 16p11.2: possible implications for Prader-Willi and Angelman syndromes.

Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide.

Random PCR mutagenesis screening of secreted proteins by direct expression in mammalian cells.

Evidence for in vitro replication of hepatitis C virus genome in a human T-cell line.

An ATP-independent U2 small nuclear ribonucleoprotein particle/precursor mRNA complex requires both splice sites and the polypyrimidine tract.

Differentiation of renal beta-intercalated cells to alpha-intercalated and principal cells in culture.

Sodium action potentials in the dendrites of cerebellar Purkinje cells.

Influence of calorie restriction on oncogene expression and DNA synthesis during liver regeneration.

The mutant axolotl Short toes exhibits impaired limb regeneration and abnormal basement membrane formation.

Zinc regulates the function of two superantigens.

Escherichia coli expressing a Neisseria gonorrhoeae opacity-associated outer membrane protein invade human cervical and endometrial epithelial cell lines.

Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype.

A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6.

Discrimination of DNA response elements for thyroid hormone and estrogen is dependent on dimerization of receptor DNA binding domains.

Nonrandom integration of retroviral DNA in vitro: effect of CpG methylation.

Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide.

Immunoelectron microscopic localization of the ubiquitin-activating enzyme E1 in HepG2 cells.

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

Control of excision frequency of maize transposable element Ds in Petunia protoplasts.

CD4 and CD8 regulate interleukin 2 responses of T cells.

A1 adenosine-receptor antagonists activate chloride efflux from cystic fibrosis cells.

Crystallization and preliminary x-ray diffraction analysis of P450terp and the hemoprotein domain of P450BM-3, enzymes belonging to two distinct classes of the cytochrome P450 superfamily.

Heterodimerization of thyroid hormone (TH) receptor with H-2RIIBP (RXR beta) enhances DNA binding and TH-dependent transcriptional activation.

Intervening sequences in an Archaea DNA polymerase gene.

Viricidal effect of stimulated human mononuclear phagocytes on human immunodeficiency virus type 1.

cAMP-mediated differential regulation of lignin peroxidase and manganese-dependent peroxidase production in the white-rot basidiomycete Phanerochaete chrysosporium.

Evidence for a substrate of neuronal plasticity based on pre- and postsynaptic neurotensin-dopamine receptor interactions in the neostriatum.

Expression cloning of a cDNA from rabbit kidney cortex that induces a single transport system for cystine and dibasic and neutral amino acids.

Stimulation of system y(+)-like amino acid transport by the heavy chain of human 4F2 surface antigen in Xenopus laevis oocytes.

Involvement of a chloroplast HSP70 heat shock protein in the integration of a protein (light-harvesting complex protein precursor) into the thylakoid membrane.

Coevolution of genes and languages revisited.

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Protein surface topology-probing by selective chemical modification and mass spectrometric peptide mapping.

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Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes.

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Coherent 25- to 35-Hz oscillations in the sensorimotor cortex of awake behaving monkeys.

Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.

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Archaea in coastal marine environments.

Expression cloning of the murine and human interleukin 9 receptor cDNAs.

Constant mean curvature surfaces constructed by fusing Wente tori.

Nucleoplasmic localization of prelamin A: Implications for prenylation-dependent lamin A assembly into the nuclear lamina

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Selective manipulation of the human T-cell receptor repertoire expressed by thymocytes in organ culture

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Zinc regulates the function of two superantigens.

Content Provider	PubMed Central
Author	Fraser, J. D. Urban, R. G. Strominger, J. L. Robinson, H.
Abstract	Staphylococcal enterotoxins bind with high affinity to class II major histocompatibility complex proteins and subsequently stimulate large numbers of T cells via the V beta portion of the T-cell receptor. Binding of enterotoxin A and enterotoxin E to HLA-DR was completely abolished by low levels of EDTA, whereas binding of toxic shock toxin was unaffected. Addition of Zn2+ to as little as 2 microM excess over EDTA completely reconstituted binding, but Ca2+, Mg2+, Cu2+, Fe2+, and Mn2+ had no effect. The dissociation constant (Kd) of 65Zn2+ binding to a single site on purified enterotoxin A was 2 microM, and addition of purified HLA-DR1 did not alter the Kd, indicating that the binding site was exclusive to enterotoxin A. In the presence of saturating levels of zinc the Kd for enterotoxin A binding to purified HLA-DR1 was 25 nM. Thus, zinc binding is an essential first step in the formation of the major histocompatibility complex binding domain of at least two bacterial superantigens. Given the measured Kd of zinc binding to enterotoxin A, serum levels of free zinc (0.2-1.0 microM) may well regulate the toxic sequelae by these two superantigens.
Starting Page	5507
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	12
Volume Number	89
Language	English
Publisher Date	1992-06-15
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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