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| Content Provider | PubMed Central |
|---|---|
| Author | Restuccia, Giovanna Boiardi, Luigi Cavazza, Alberto Catanoso, Mariagrazia Macchioni, Pierluigi Muratore, Francesco Cimino, Luca Aldigeri, Raffaella Crescentini, Filippo Pipitone, Nicolò Carlo, Salvarani |
| Editor | Zeron, Pilar Brito |
| Copyright Year | 2016 |
| Abstract | This study evaluated the frequency, timing, and characteristics of flares in a large cohort of Italian patients with biopsy-proven giant cell arteritis (GCA) and to identify factors at diagnosis able to predict the occurrence of flares. We evaluated 157 patients with biopsy-proven transmural GCA diagnosed and followed at the Rheumatology Unit of Reggio Emilia Hospital (Italy) for whom sufficient information was available from the time of diagnosis until at least 4 years of follow-up. Fifty-seven patients (36.5%) experienced ≥1 flares. Fifty-one (46.4%) of the 110 total flares (88 relapses and 22 recurrences) were experienced during the first 2 years after diagnosis. The majority of relapses occurred with doses of prednisone ≤ 10 mg/day (82.9%), whereas only 3.4% of relapses occurred for doses ≥ 25 mg/day. Polymyalgia rheumatica (46.5%) and cranial symptoms (41.9%) were the most frequent manifestations at the time of the first relapse. Cumulative prednisone dose during the first year and total cumulative prednisone dose were significantly higher in flaring patients compared with those without flares (7.8 ± 2.4 vs 6.7 ± 2.4 g, P = 0.02; 15.5 ± 8.9 vs 10.0 ± 9.2 g, P = 0.0001, respectively). The total duration of prednisone treatment was longer in flaring patients (58 ± 44 vs 30 ± 30 months, P = 0.0001). |
| Related Links | http://dx.doi.org/10.1097/MD.0000000000003524 |
| Starting Page | 3524 |
| File Format | |
| ISSN | 15365964 |
| e-ISSN | 15365964 |
| Journal | Medicine |
| Issue Number | 19 |
| Volume Number | 95 |
| Language | English |
| Publisher | Wolters Kluwer Health |
| Publisher Date | 2016-05-13 |
| Access Restriction | Open |
| Rights Holder | Wolters Kluwer Health |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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