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| Content Provider | PubMed Central |
|---|---|
| Author | Mets, E. Meulen, J. Van Der Peer, G. Van Boice, M. Mestdagh, P. Lammens, T. Goossens, S. De, Moerloose B. Benoit, Y. Roy, N. Van Clappier, E. Poppe, B. Vandesompele, J. Wendel, H-g Taghon, T. Rondou, P. Soulier, J. Vlierberghe, P. Van Speleman, F. Van De Walle, I. |
| Abstract | The MYB oncogene is a leucine zipper transcription factor essential for normal and malignant hematopoiesis. In T-cell acute lymphoblastic leukemia (T-ALL), elevated MYB levels can arise directly through T-cell receptor-mediated MYB translocations, genomic MYB duplications or enhanced TAL1 complex binding at the MYB locus or indirectly through the TAL1/miR-223/FBXW7 regulatory axis. In this study, we used an unbiased MYB 3′untranslated region–microRNA (miRNA) library screen and identified 33 putative MYB-targeting miRNAs. Subsequently, transcriptome data from two independent T-ALL cohorts and different subsets of normal T-cells were used to select miRNAs with relevance in the context of normal and malignant T-cell transformation. Hereby, miR-193b-3p was identified as a novel bona fide tumor-suppressor miRNA that targets MYB during malignant T-cell transformation thereby offering an entry point for efficient MYB targeting-oriented therapies for human T-ALL. |
| Related Links | http://dx.doi.org/10.1038/leu.2014.276 |
| Ending Page | 806 |
| Page Count | 9 |
| Starting Page | 798 |
| File Format | |
| ISSN | 08876924 |
| e-ISSN | 14765551 |
| Journal | Leukemia |
| Issue Number | 4 |
| Volume Number | 29 |
| Language | English |
| Publisher Date | 2015-04-01 |
| Access Restriction | Open |
| Subject Keyword | Anesthesiology and Pain Medicine Cancer Research Hematology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Cancer Research Anesthesiology and Pain Medicine Oncology |
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