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| Content Provider | PubMed Central |
|---|---|
| Author | Khandelwal, Nitesh Kumar Philipp, Kaemmer Förster, Toni M. Singh, Ashutosh Coste, Alix T. Andes, David R. Hube, Bernhard Dominique, Sanglard Chauhan, Neeraj Kaur, Rupinder Christophe, D'enfert Mondal, Alok Kumar Prasad, Rajendra |
| Copyright Year | 2016 |
| Abstract | Among the several mechanisms that contribute to MDR (multidrug resistance), the overexpression of drug-efflux pumps belonging to the ABC (ATP-binding cassette) superfamily is the most frequent cause of resistance to antifungal agents. The multidrug transporter proteins Cdr1p and Cdr2p of the ABCG subfamily are major players in the development of MDR in Candida albicans. Because several genes coding for ABC proteins exist in the genome of C. albicans, but only Cdr1p and Cdr2p have established roles in MDR, it is implicit that the other members of the ABC family also have alternative physiological roles. The present study focuses on an ABC transporter of C. albicans, Mlt1p, which is localized in the vacuolar membrane and specifically transports PC (phosphatidylcholine) into the vacuolar lumen. Transcriptional profiling of the mlt1∆/∆ mutant revealed a down-regulation of the genes involved in endocytosis, oxidoreductase activity, virulence and hyphal development. High-throughput MS-based lipidome analysis revealed that the Mlt1p levels affect lipid homoeostasis and thus lead to a plethora of physiological perturbations. These include a delay in endocytosis, inefficient sequestering of reactive oxygen species (ROS), defects in hyphal development and attenuated virulence. The present study is an emerging example where new and unconventional roles of an ABC transporter are being identified. |
| Related Links | http://dx.doi.org/10.1042/bcj20160024 |
| Ending Page | 1552 |
| Page Count | 16 |
| Starting Page | 1537 |
| File Format | |
| ISSN | 02646021 |
| e-ISSN | 14708728 |
| Journal | Biochemical Journal |
| Issue Number | 11 |
| Volume Number | 473 |
| Language | English |
| Publisher | Portland Press Ltd. |
| Publisher Date | 2016-06-01 |
| Access Restriction | Open |
| Rights Holder | Portland Press Ltd. |
| Subject Keyword | Cell Biology Biochemistry Molecular Biology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology Biochemistry |
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