NDLI: Living biofouling-resistant membranes as a model for the beneficial use of engineered biofilms

Content Provider	PubMed Central
Author	Wood, Thammajun L. Guha, Rajarshi Tang, Li Geitner, Michael Kumar, Manish Wood, Thomas K.
Abstract	Biofouling is a significant problem for membrane-based systems because it reduces flow and increases energy consumption. This work shows a previously unreported approach to prevent membrane biofouling by using a beneficial biofilm. The beneficial strain was engineered to have a dispersal “feedback circuit,” based on secretion and uptake of a communication signal, limiting its own biofilm formation by self-monitoring and selective dispersal. The beneficial strain was also engineered to produce nitric oxide, which prevents biofilm formation by harmful bacteria; biofouling by the two most prevalent organisms was shown to be controlled by the beneficial strain. Moreover, the beneficial biofilm was engineered to produce an evolved epoxide hydrolase to enable it to remove the environmental pollutant epichlorohydrin.
Related Links	http://dx.doi.org/10.1073/pnas.1521731113
Starting Page	2802
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	20
Volume Number	113
Language	English
Publisher	National Academy of Sciences
Publisher Date	2016-05-17
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Living biofouling-resistant membranes as a model for the beneficial use of engineered biofilms