NDLI: Increased apolipoprotein E and c-fms gene expression without elevated interleukin 1 or 6 mRNA levels indicates selective activation of macrophage functions in advanced human atheroma.

Please wait, while we are loading the content...

Year: 2016, Volume: 113

Year: 2015, Volume: 112

Year: 2014, Volume: 111

Year: 2013, Volume: 110

Year: 2012, Volume: 109

Year: 2011, Volume: 109

Year: 2011, Volume: 108

Year: 2010, Volume: 107

Year: 2009, Volume: 106

Year: 2009, Volume: 94

Year: 2008, Volume: 105

Year: 2007, Volume: 104

Year: 2006, Volume: 103

Year: 2005, Volume: 103

Year: 2005, Volume: 102

Year: 2004, Volume: 101

Year: 2003, Volume: 100

Year: 2002, Volume: 99

Year: 2001, Volume: 98

Year: 2000, Volume: 97

Year: 1999, Volume: 96

Year: 1998, Volume: 95

Year: 1997, Volume: 94

Year: 1996, Volume: 93

Year: 1995, Volume: 92

Year: 1994, Volume: 91

Year: 1993, Volume: 90

Year: 1992, Volume: 89

Year: 1992, Volume: 89, Issue: 24

Year: 1992, Volume: 89, Issue: 23

Year: 1992, Volume: 89, Issue: 22

Year: 1992, Volume: 89, Issue: 21

Year: 1992, Volume: 89, Issue: 20

Year: 1992, Volume: 89, Issue: 19

Year: 1992, Volume: 89, Issue: 18

Year: 1992, Volume: 89, Issue: 17

Year: 1992, Volume: 89, Issue: 16

Year: 1992, Volume: 89, Issue: 15

Year: 1992, Volume: 89, Issue: 14

Year: 1992, Volume: 89, Issue: 13

Year: 1992, Volume: 89, Issue: 12

Year: 1992, Volume: 89, Issue: 11

Year: 1992, Volume: 89, Issue: 10

Year: 1992, Volume: 89, Issue: 9

Year: 1992, Volume: 89, Issue: 8

Year: 1992, Volume: 89, Issue: 7

A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon.

Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells.

Probing the energetics of oligo(dT).poly(dA) by laser cross-linking.

Tolerance induction by thymic medullary epithelium.

High frequency of single-base transitions and extreme frequency of precise multiple-base reversion mutations in poliovirus.

A lattice model for protein structure prediction at low resolution.

Establishment and characterization of lymphoid and myeloid mixed-cell populations from mouse late embryoid bodies, "embryonic-stem-cell fetuses".

Anti-idiotype monoclonal antibody elicits broadly neutralizing anti-gp120 antibodies in monkeys.

Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients.

Genetic structure of forensic populations.

Multiple sulfatase deficiency: catalytically inactive sulfatases are expressed from retrovirally introduced sulfatase cDNAs.

Serotype conversion in Vibrio cholerae O1.

Chronic deafferentation in monkeys differentially affects nociceptive and nonnociceptive pathways distinguished by specific calcium-binding proteins and down-regulates gamma-aminobutyric acid type A receptors at thalamic levels.

Postsynaptic protein kinase C essential to induction and maintenance of long-term potentiation in the hippocampal CA1 region.

Adenovirus as an expression vector in muscle cells in vivo.

In vivo T-cell ablation by a holo-immunotoxin directed at human CD3.

Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainate in cultured cerebral cortical neurons.

First-order analysis of optical flow in monkey brain.

Expression of a bacterial mtlD gene in transgenic tobacco leads to production and accumulation of mannitol.

A uridine-rich sequence required for translation of prokaryotic mRNA.

Synthesis of the early light-inducible protein is controlled by blue light and related to light stress.

What is the optimum size for the genetic alphabet?

Heterogeneous expression of glucokinase among pancreatic beta cells.

Modification of Brassica seed oil by antisense expression of a stearoyl-acyl carrier protein desaturase gene.

Simulations of the folding pathway of triose phosphate isomerase-type alpha/beta barrel proteins.

Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury.

Nerve growth factor-induced synaptogenesis and hypertrophy of cortical cholinergic terminals.

sar: a genetic mouse model for human sarcosinemia generated by ethylnitrosourea mutagenesis.

Expression of a cloned rat histamine H2 receptor mediating inhibition of arachidonate release and activation of cAMP accumulation.

DNA helical stability accounts for mutational defects in a yeast replication origin.

AlgR2 is an ATP/GTP-dependent protein kinase involved in alginate synthesis by Pseudomonas aeruginosa.

Ligand and DNA-dependent phosphorylation of human progesterone receptor in vitro.

Cloning and physical mapping of the HLA class I region spanning the HLA-E-to-HLA-F interval by using yeast artificial chromosomes.

Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line.

Infectious Sindbis virus transient expression vectors for studying antigen processing and presentation.

Murine monoclonal anti-idiotope antibody breaks unresponsiveness and induces a specific antibody response to human melanoma-associated proteoglycan antigen in cynomolgus monkeys.

Retinoic acid mimics transforming growth factor beta in the regulation of human immunodeficiency virus expression in monocytic cells.

Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia.

16S rRNA phylogenetic analysis of the bacterial endosymbionts associated with cytoplasmic incompatibility in insects.

Gene expression in Leishmania: analysis of essential 5' DNA sequences.

Regulation of hepatitis B virus gene expression by its two enhancers.

Transport and anchoring of beta-lactamase to the external surface of Escherichia coli.

RAR-beta 4, a retinoic acid receptor isoform is generated from RAR-beta 2 by alternative splicing and usage of a CUG initiator codon.

Specific binding of arginine to TAR RNA.

Symmetry conditions for binding processes.

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

Functional characterization of a hybrid human-mouse interferon gamma receptor: evidence for species-specific interaction of the extracellular receptor domain with a putative signal transducer.

Sequence of Prochloron didemni atpBE and the inference of chloroplast origins.

Origin of Gila seminuda (Teleostei: Cyprinidae) through introgressive hybridization: implications for evolution and conservation.

A common antiviral cytotoxic T-lymphocyte epitope for diverse major histocompatibility complex haplotypes: implications for vaccination.

Expression of urinary H-2 odortypes by infant mice.

Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1.

Pituitary hyperplasia induced by ectopic expression of nerve growth factor.

Stimulation of protein-tyrosine phosphorylation in rat striatum after lesion of dopamine neurons or chronic neuroleptic treatment.

Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors.

Epinephrine suppresses rap1B.GAP-activated GTPase activity in human platelets.

Interleukin (IL)-2 and IL-3 induce distinct but overlapping responses in murine IL-3-dependent 32D cells transduced with human IL-2 receptor beta chain: involvement of tyrosine kinase(s) other than p56lck.

Single-residue changes in class I major histocompatibility complex molecules stimulate responses to self peptides.

Three lymphoid-specific factors account for all junctional diversity characteristic of somatic assembly of T-cell receptor and immunoglobulin genes.

Isolation of a candidate human hematopoietic stem-cell population.

Increased apolipoprotein E and c-fms gene expression without elevated interleukin 1 or 6 mRNA levels indicates selective activation of macrophage functions in advanced human atheroma.

Synergistic suppression: anomalous inhibition of the proliferation of factor-dependent hemopoietic cells by combination of two colony-stimulating factors.

Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.

Thymidine-induced mutations in mammalian cells: sequence specificity and implications for mutagenesis in vivo.

High-affinity ouabain binding by yeast cells expressing Na+, K(+)-ATPase alpha subunits and the gastric H+, K(+)-ATPase beta subunit.

Isolation and characterization of a cDNA encoding Drosophila transcription factor TFIIB.

A bipartite DNA binding domain composed of direct repeats in the TATA box binding factor TFIID.

Plasma membrane inositol 1,4,5-trisphosphate receptor of lymphocytes: selective enrichment in sialic acid and unique binding specificity.

Demonstration of processing and recycling of biologically active V1 vasopressin receptors in vascular smooth muscle.

Chlorambucil-induced mutations in mice recovered in homozygotes.

An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals.

Functional analysis of a type IIB von Willebrand disease missense mutation: increased binding of large von Willebrand factor multimers to platelets.

Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation end products is mediated via platelet-derived growth factor.

A protein kinase associated with paired helical filaments in Alzheimer disease.

Hox-1.11 and Hox-4.9 homeobox genes.

Photoaffinity labeling of the primary fibrin polymerization site: isolation and characterization of a labeled cyanogen bromide fragment corresponding to gamma-chain residues 337-379.

Photoaffinity labeling of the primary fibrin polymerization site: localization of the label to gamma-chain Tyr-363.

Cap-specific mRNA (nucleoside-O2'-)-methyltransferase and poly(A) polymerase stimulatory activities of vaccinia virus are mediated by a single protein.

Spectroscopic evidence for conformational relaxation in myoglobin.

CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.

Mutual relationships between chromogranins A and B and gastrin in individual gastrin cells.

p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15.

Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase.

Multiple occurrences of mutualism in the yucca moth lineage.

On the nature of global classification

Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability.

Structure-function relationship among T-cell receptors specific for lysozyme peptides bound to Ab or Abm-12 molecules.

Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5.

Abnormal secretagogue-induced intracellular free Ca2+ regulation in cystic fibrosis nasal epithelial cells.

K-sam gene encodes secreted as well as transmembrane receptor tyrosine kinase.

Structural alterations of the epidermal growth factor receptor gene in human gliomas.

Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine.

Synthesis of 5-methylaminomethyl-2-selenouridine in tRNAs: 31P NMR studies show the labile selenium donor synthesized by the selD gene product contains selenium bonded to phosphorus.

Cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p.

T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice.

Interaction of the pertussis toxin peptide containing residues 30-42 with DR1 and the T-cell receptors of 12 human T-cell clones.

Theory of hydrophobicity: Transient cavities in molecular liquids

Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina.

Expression of alternatively spliced human T-lymphotropic virus type I pX mRNA in infected cell lines and in primary uncultured cells from patients with adult T-cell leukemia/lymphoma and healthy carriers.

Analysis of gene expression in single live neurons.

On the identity of the major postsynaptic density protein.

Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers.

Suramin is an inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells.

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

Role of neuromedin B in control of the release of thyrotropin in hypothyroid and hyperthyroid rats.

Characterization of the 5' flanking region of the human D1A dopamine receptor gene.

Hormone-induced progesterone receptor phosphorylation consists of sequential DNA-independent and DNA-dependent stages: analysis with zinc finger mutants and the progesterone antagonist ZK98299.

Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein.

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

Alteration of a protease-sensitive region of Pseudomonas exotoxin prolongs its survival in the circulation of mice.

High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.

Independent domain folding of Pseudomonas exotoxin and single-chain immunotoxins: influence of interdomain connections.

Isolation and sequence analysis of the cDNA for pig kidney fructose 1,6-bisphosphatase.

Uncoupling of the DNA topoisomerase and replication activities of an initiator protein.

Transactivation and transformation by Myb are negatively regulated by a leucine-zipper structure.

Coordinated synthesis and degradation of cdc2 in the mammalian cell cycle.

Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiae.

A 36-base-pair core sequence of locus control region enhances retrovirally transferred human beta-globin gene expression.

Expression, regulation, and chromosomal localization of the Max gene.

Stable growth transformation of human T lymphocytes by herpesvirus saimiri.

A growth-regulated protease activity that is inhibited by the anticarcinogenic Bowman-Birk protease inhibitor.

Purification, molecular cloning, and functional expression of the cholecystokinin receptor from rat pancreas.

Developmental and environmental regulation of a mammary gland-specific nuclear factor essential for transcription of the gene encoding beta-casein.

Vesicular stomatitis virus antigenic octapeptide N52-59 is anchored into the groove of the H-2Kb molecule by the side chains of three amino acids and the main-chain atoms of the amino terminus.

A transcriptional silencer downstream of the promoter in the osmotically controlled proU operon of Salmonella typhimurium.

The effects of dietary restriction on immune function and development of autoimmune disease in BXSB mice.

Memory cell generation ablated by soluble protein antigen by means of effects on T- and B-lymphocyte compartments.

Induction of heat shock protein closely correlates with protection against Toxoplasma gondii infection.

Disruption of either the E1 or the E2 regulatory gene of human papillomavirus type 16 increases viral immortalization capacity.

Year: 1992, Volume: 89, Issue: 6

Year: 1992, Volume: 89, Issue: 5

Year: 1992, Volume: 89, Issue: 4

Year: 1992, Volume: 89, Issue: 3

Year: 1992, Volume: 89, Issue: 2

Year: 1992, Volume: 89, Issue: 1

Year: 1991, Volume: 88

Year: 1990, Volume: 87

Year: 1989, Volume: 86

Year: 1988, Volume: 85

Year: 1987, Volume: 84

Year: 1986, Volume: 83

Year: 1985, Volume: 82

Year: 1984, Volume: 81

Year: 1983, Volume: 80

Year: 1982, Volume: 79

Year: 1981, Volume: 78

Year: 1980, Volume: 77

Year: 1979, Volume: 76

Year: 1978, Volume: 75

Year: 1977, Volume: 74

Year: 1976, Volume: 73

Year: 1975, Volume: 72

Year: 1974, Volume: 71

Year: 1973, Volume: 70

Year: 1972, Volume: 69

Year: 1971, Volume: 68

Year: 1970, Volume: 67

Year: 1970, Volume: 66

Year: 1970, Volume: 65

Year: 1969, Volume: 64

Year: 1969, Volume: 63

Year: 1969, Volume: 62

Year: 1968, Volume: 61

Year: 1968, Volume: 60

Year: 1968, Volume: 59

Year: 1967, Volume: 58

Year: 1967, Volume: 57

Year: 1966, Volume: 56

Year: 1966, Volume: 55

Year: 1965, Volume: 54

Year: 1965, Volume: 53

Year: 1964, Volume: 52

Year: 1964, Volume: 51

Year: 1963, Volume: 50

Year: 1963, Volume: 49

Year: 1962, Volume: 48

Year: 1961, Volume: 47

Year: 1960, Volume: 46

Year: 1959, Volume: 45

Year: 1958, Volume: 44

Year: 1957, Volume: 43

Year: 1956, Volume: 42

Year: 1955, Volume: 41

Year: 1954, Volume: 40

Year: 1953, Volume: 39

Year: 1952, Volume: 38

Year: 1951, Volume: 37

Year: 1950, Volume: 36

Year: 1949, Volume: 35

Year: 1948, Volume: 34

Year: 1947, Volume: 33

Year: 1946, Volume: 32

Year: 1945, Volume: 31

Year: 1944, Volume: 30

Year: 1943, Volume: 29

Year: 1942, Volume: 28

Year: 1941, Volume: 27

Year: 1940, Volume: 26

Year: 1939, Volume: 25

Year: 1938, Volume: 24

Year: 1937, Volume: 23

Year: 1936, Volume: 22

Year: 1935, Volume: 21

Year: 1934, Volume: 20

Year: 1933, Volume: 19

Year: 1932, Volume: 18

Year: 1931, Volume: 17

Year: 1930, Volume: 16

Year: 1929, Volume: 15

Year: 1928, Volume: 14

Year: 1927, Volume: 13

Year: 1926, Volume: 12

Year: 1925, Volume: 11

Year: 1924, Volume: 10

Year: 1923, Volume: 9

Year: 1922, Volume: 8

Year: 1921, Volume: 7

Year: 1920, Volume: 6

Year: 1919, Volume: 5

Year: 1918, Volume: 4

Year: 1917, Volume: 3

Year: 1916, Volume: 2

Year: 1915, Volume: 1

Increased apolipoprotein E and c-fms gene expression without elevated interleukin 1 or 6 mRNA levels indicates selective activation of macrophage functions in advanced human atheroma.

Content Provider	PubMed Central
Author	Salomon, R. N. Underwood, R. Wang, A. Libby, P. Doyle, M. V.
Abstract	Cells found within atherosclerotic lesions can produce in culture protein mediators that may participate in atherogenesis. To test whether human atheromata actually contain transcripts for certain of these genes, we compared levels of mRNAs in carotid or coronary atheromata and in nonatherosclerotic human vessels by polymerase chain reaction (PCR) amplification of cDNAs reverse-transcribed from RNA. We measured PCR products (generated during exponential amplification) by incorporation of 32P-labeled primers. Levels of interleukin 1 alpha, 1 beta, or 6 mRNAs in plaques and controls did not differ. Compared to uninvolved vessels, plaques did contain higher levels of mRNA encoding platelet-derived growth factor A chain (42 +/- 24 vs. 12 +/- 10 fmol of product; mean +/- SD; n = 8 and 8, respectively; P = 0.007) and B chain (41 +/- 36 vs. 4 +/- 3 fmol of product, n = 14 and 6, respectively; P = 0.024). Atherosclerotic lesions consistently had much higher levels of apolipoprotein E (apoE) mRNA than did control vessels (131 +/- 71 vs. 5 +/- 3 fmol of product; n = 12 and 10, respectively; P less than 0.001). Direct RNA blot analyses confirmed elevated levels of apoE mRNA in plaque extracts. To test whether mononuclear phagocytes might be a source of the apoE mRNA, we studied a selective marker for cells of the monocytic lineage, the c-fms protooncogene, which encodes the receptor for macrophage colony-stimulating factor. Plaques also contained elevated levels of c-fms mRNA (30 +/- 17 vs. 5 +/- 3 fmol of product; n = 10 and 7, respectively; P = 0.002). Immunohistochemical colocalization demonstrated apoE protein in association with macrophages in plaques, whereas nonatherosclerotic vessels showed no immunoreactive apoE. ApoE produced locally in atheroma might modulate the functions of lesional T cells or promote "reverse cholesterol transport" by associating with high density lipoprotein particles, thus targeting them for peripheral uptake. Macrophages within the advanced human atheroma appear to exhibit a selective program of activation as they express high levels of apoE, whereas overall levels of interleukin 1 or 6 mRNAs in plaques are not elevated.
Starting Page	2814
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	89
Language	English
Publisher Date	1992-04-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in