NDLI: Co-Expression of p16, Ki67 and COX-2 Is Associated with Basal Phenotype in High-Grade Ductal Carcinoma In Situ of the Breast

Content Provider	PubMed Central
Author	Perez, Amanda Arantes Balabram, Débora Rocha, Rafael Malagoli Souza, Átila Da Silva Gobbi, Helenice
Copyright Year	2015
Abstract	We assessed the co-expression of cell cycle-related biomarkers in a series of 121 consecutive cases of high-grade ductal carcinoma in situ (DCIS), pure or associated with invasive carcinoma, and their associations with the different immunoprofiles of DCIS. Cases were identified from the histopathology files of the Breast Pathology Laboratory, Federal University of Minas Gerais, Brazil, from 2003 to 2008. The expression of estrogen receptor, progesterone receptor, HER2 overexpression, cytokeratin 5, epidermal growth factor receptor 1, cyclooxygenase-2, p16 and Ki67 were assessed. Tumors were placed into five subgroups according to their immunohistochemical profile: luminal A, luminal B, HER2, basal-like and “not classified”. We found that the basal phenotype was associated with a higher frequency of p16-positive cases (83%) and the luminal A phenotype showed a higher frequency of p16-negative cases (93%; p=0.000). The association of biomarkers p16+/Ki67+/COX2+ was expressed in 02/06 cases (33.3%) of the basal phenotype but in only 01/70 cases (1.4%) of the luminal A phenotype (p=0.01). The co-expression of p16+/Ki67+/COX2- was associated with a basal phenotype (p=0.004). P16 expression, p16+/Ki67+/COX2+ and p16+/Ki67+/COX2- co-expression showed significant associations with the basal phenotype and these profiles could be used to guide more aggressive treatment strategies in patients with high-grade DCIS.
Related Links	http://dx.doi.org/10.1369/0022155415576540
Ending Page	416
Page Count	9
Starting Page	408
File Format	PDF
ISSN	00221554
e-ISSN	15515044
Journal	Journal of Histochemistry and Cytochemistry
Issue Number	6
Volume Number	63
Language	English
Publisher	SAGE Publications
Publisher Date	2015-06-01
Access Restriction	Open
Rights Holder	SAGE Publications
Subject Keyword	Anatomy Histology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Anatomy Histology

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